颈动脉内膜中层厚度和绝经后妇女骨密度相关性研究

Relationship between carotid intima-media thickness and bone mineral density in postmenopausal women

目的探讨绝经后骨质疏松症患者颈动脉内膜中层厚度(CIMT)的差异及CIMT和斑块增大的风险。方法进行横断面研究,包括60位绝经后骨质疏松症妇女和60位非骨质疏松症绝经后妇女。CIMT采用B型超声测量。结果绝经后骨质疏松症妇女与无骨质疏松症妇女的平均CIMT差异无统计学意义(P> 0.05)。骨质疏松症组CIMT升高的风险与非骨质疏松症组相似。骨质疏松症妇女斑块出现的风险是正常人的三倍。然而,调整了易使妇女患有心血管疾病的年龄和基础疾病后,两组之间斑块的存在并无显着差异(校正比值比=0.85;95%可信区间0.10～6.464)。结论绝经后妇女与无骨质疏松症患者的平均CIMT无差异。绝经后骨质疏松症女性的CIMT升高风险与无骨质疏松症的绝经后妇女相当。两组之间斑块的存在没有显着差异。

Objective To explore the difference in carotid intima-media thickness(CIMT) between postmenopausal women with and without osteoporosis and the risk of elevated CIMT and plaque presentation. Methods A cross-sectional study was conducted including 60 postmenopausal women with osteoporosis and 60 non-osteoporotic postmenopausal women. CIMT was measured using B-mode ultrasound. Results There was no statistically significant difference in mean CIMT between postmenopausal women with osteoporosis and without osteoporosis(P>0.05). Risk for elevated CIMT in the osteoporosis group was comparable to that of the non-osteoporosis group(adjusted odds ratio=0.85;95% confidence interval 0.10~6.46). The risk for the presence of plaque was three times higher in osteoporotic women than in normal individuals. However, after adjusting for age and underlying diseases that would predispose the women to cardiovascular disease, there was no significant difference in terms of presence of plaque between the two groups(adjusted odds ratio=0.844;95% confidence interval 0.11-6.45). Conclusion There was no difference in mean CIMT between postmenopausal women with and without osteoporosis. Risk of elevated CIMT in postmenopausal women with osteoporosis was comparable to that of postmenopausal women without osteoporosis. There was no significant difference between the two groups in terms of the presence of plaque.