三种不同他汀类药物对去卵巢诱导骨质疏松大鼠骨密度的影响

Effects of three different types of statin on bone mineral density in ovariectomized rats with osteoporosis

目的研究三种不同的他汀类药物对卵巢切除(OVX)雌性Sprague-Dawley大鼠的治疗效果,并比较其对大鼠骨密度的影响。方法在切除大鼠卵巢12周后,分别用生理盐水、阿托伐他汀、辛伐他汀和洛伐他汀治疗OVX大鼠。治疗2个月后,在实验结束时对大鼠进行安乐死,获取其血清和股骨。通过生物力学测试、Micro-CT扫描和血清生化分析评估治疗的效果。结果与未处理的OVX大鼠相比,辛伐他汀、阿托伐他汀和洛伐他汀的全身给药显著增加了血清成骨指标、骨密度(bone mineral density, BMD)和生物力学指标(P<0.05)。结论辛伐他汀、阿托伐他汀和洛伐他汀能有效改善OVX诱导的骨质疏松症。此外,经辛伐他汀治疗的动物的BMD、血清骨代谢指标和生物力学性能都显示了较好的结果。

Objective We investigated the therapeutic effects of the most important types of statin administered orally for 2 months to ovariectomized(OVX)female Sprague-Dawley rats and compared the effects on bone mineral density.Methods 12 months after ovariectomy,the OVX rats were treated with normal saline,atorvastatin,simvastatin and lovastatin.The osteoporotic animals were treated daily for 2 months and euthanized at the end of experiments.The effectiveness of these treatments was evaluated by biomechanical testing,micro-CT scan and serum biochemical analysis.Results The result and statistical analysis showed that systemic delivery of simvastatin,atorvastatin and lovastatin significantly increased serum osteogenic indexes,bone mineral density(BMD)and biomechanical properties in comparison with the untreated OVX rats(P<0.05).In all treatment groups,the SIM group achieved the best result.Conclusion It was concluded that simvastatin,atorvastatin and lovastatin could efficiently ameliorate the OVX-induced osteoporosis.Moreover,the simvastatin-treated animals showed the best result in terms of BMD,serum bone metabolic indexes and biomechanical properties.