维生素K2(MK-7)防治骨质疏松的作用机制研究进展

Update on the mechanism of vitamin K2 (MK-7) in preventing and treating osteoporosis

维生素K2具有抗骨质疏松的骨骼健康效应。在维生素K2系列中MK-7的活性最强。经成骨细胞、破骨细胞培养的体外机制分析及去卵巢骨质疏松模型、去神经骨质疏松模型、悬吊骨质疏松模型、肥胖骨质疏松模型和临床研究,揭示MK-7抗骨质疏松的作用机制:①通过维生素K2依赖性蛋白的γ-羧基化途径,将骨钙素分子中的谷氨酸残基羧化;②通过刺激成骨细胞分化、调控骨细胞外基质矿化、上调骨标志物基因表达、抑制破骨细胞生成,促进骨形成和降低骨吸收。

Vitamin K2 plays anti-osteoporosis effect on bone health.MK-7 has the strongest activity in vitamin K2 series.The mechanism of anti-osteoporosis of MK-7 was revealed by in vitro analysis of osteoblasts and osteoclasts culture,ovariectomized osteoporosis model,denervated osteoporosis model,suspended osteoporosis model,obese osteoporosis model and clinical research.The mechanism of anti-osteoporosis of MK-7:①γ-Carboxylation of glutamate residue in osteocalcin molecule through the carboxylation pathway of vitamin K2-dependent protein;②Inhibiting osteoclast formation,promoting bone formation and reducing bone resorption,through stimulation of osteoblast differentiation,regulation of bone extracellular matrix mineralization and up-regulation of gene expression of bone markers.