血清脂肪因子-CTRP3水平与绝经后妇女骨密度相关性研究

Relationship between serum adipokine-CTRP3 and osteoporosis in postmenopausal women

目的观察血清脂肪因子-CTRP3水平与绝经后妇女骨密度的相关性。方法选取2016年7月至2017年8月在我院就诊的192名绝经后女性,检测其CTRP3和骨钙素的血清水平。使用双能X线骨密度仪检测股骨颈和腰椎的骨密度(bone mineral density,BMD)。结果骨质疏松患者血清CTRP3水平[(75.5±20.6) ng/mL]低于对照组[(88.7±21.8) ng/mL](P<0.001)。同时,在血清CTRP3的三分位数中,骨质疏松症的频率显著降低(66.6%、53.4%和35.3%,P<0.001)。此外,血清CTRP3与骨质疏松症风险较低相关[校正比值比=0.975,95%CI(0.962~0.987),P<0.001]。最后,在所有参与者中,血清CTRP3水平与调整后股骨BMD(r=0.423,P<0.001)、腰椎BMD(r=0.358,P<0.001)和HDL-C(r=0.123,P=0.014)呈正相关。同时,CTRP3与HOMA-IR(r=-0.127,P=0.005)和胰岛素(r=-0.187,P<0.001)呈负相关。结论血清CTRP3水平降低与绝经后女性骨密度降低密切相关。

Objective A hospital-based case-control study was conducted to investigate the role of serum CTRP3 in osteoporosis among postmenopausal women.Methods Serum levels of CTRP3 and osteocalcin were measured in 192 postmenopausal women who presented in our hospital between July 2016 and August 2017.Bone mineral density(BMD)of femoral neck and lumbar spines was measured by dual energy X-ray absorptiometry.Results Serum CTRP3 level was lower in subjects with osteoporosis(75.5±20.6 ng/mL)than in controls(88.7±21.8 ng/mL)(P<0.001).Meanwhile,the frequency of osteoporosis presented a significant decrease(66.6%,53.4%and 35.3%,P<0.001)in the tertiles of serum CTRP3.Furthermore,serum CTRP3 was associated with a lower risk of osteoporosis(adjusted odds ratio=0.975,95%CI[0.962-0.987],P<0.001).Lastly,serum CTRP3 level positively correlated with femoral BMD(r=0.423,P<0.001),lumbar BMD(r=0.358,P<0.001),and HDL-C(r=0.123,P=0.014)among all participants after adjustment.Meanwhile,CTRP3 presented negative correlations with HOMA-IR(r=-0.127,P=0.005)and insulin(r=-0.187,P<0.001).Conclusion Our findings suggest that decreased serum level of CTRP3 was independently associated with osteoporosis.