摘要
运用多种色谱技术,对海南栽培肾茶地上部分的化学成分进行分离,并根据波谱数据结合理化性质共鉴定了6个单体化合物的结构,分别为1-dehydroxy-1-oxo-rupestrinol (1),N-反式阿魏酰酪胺(2),丹参素甲酯(3),咖啡酸(4),咖啡酸甲酯(5)和咖啡酸乙酯(6),其中化合物1为新的倍半萜类化合物,化合物2和3为首次从肾茶中分离得到。活性测试结果显示,化合物2～4呈现不同程度的α-葡萄糖苷酶抑制活性。
Six compounds were isolated from the aerial part of cultivated Clerodendranthus spicatus in Hainan with various chromatographic techniques,and their structures were determined as:1-dehydroxy-1-oxo-rupestrinol(1),N-trans-feruloyltyramine(2),methyl 3,4-dihydroxyphenyllactate(3),caffein acid(4),methyl caffeate(5) and ethyl caffeate(6),via analysis of physicochemical properties and spectroscopic evidence.Compound 1 was a new compound,while compounds 2 and 3 were isolated from C.spicatus for the first time.Biological activity results showed that compounds 2-4 exhibited α-glucosidase inhibitory activity with different inhibition ratio.
作者
陈惠琴
张荣荣
梅文莉
蔡彩虹
盖翠娟
于旭东
戴好富
CHEN Hui-qin;ZHANG Rong-rong;MEI Wen-li;CAI Cai-hong;GAI Cui-juan;YU Xu-dong;DAI Hao-fu(Key Laboratory of Biology and Genetic Resources of Tropical Crops,Ministry of Agriculture,Chinese Academy of Tropical Agricultural Sciences,Haikou 571101,China;Hainan Key Laboratory for Research and Development of Natural Products from Li Folk Medicine,Haikou 571101,China;College of Agronomy,Hainan University,Haikou 570228,China)
出处
《中国中药杂志》
CAS
CSCD
北大核心
2019年第1期95-99,共5页
China Journal of Chinese Materia Medica
基金
海南省自然科学基金创新研究团队项目(2017CXTD020)
中国热带农业科学院基本科研业务费专项资金项目(17CXTD-15
1630052016008)
现代农业产业技术体系建设专项资金项目(CARS-21)
关键词
肾茶
桉烷型倍半萜
Α-葡萄糖苷酶
Clerodendranthus spicatus
eudesmane type sesquiterpene
α-glucosidase inhibitory activity
