骆驼蓬种子中的含氮化合物

N-containing compounds from seeds of Paganum harmala

为研究骆驼蓬Paganum harmala种子中的含氮类活性化合物,该文综合利用硅胶、MCI和ODS柱色谱以及半制备高效液相分离等多种色谱分离技术,从骆驼蓬种子95%乙醇提取物中分离得到14个含氮化合物,并利用波谱学技术鉴定了全部化合物的结构,分别为N-[3-(2-amino-4-methoxyphenyl)-3-oxopropyl]acetamide(1),dehydroharmalacidine(2),harmalacidine(3),harmine N-oxide(4),harmine(5),tetrahydroharmine(6),demethylharmalacidine(7),harmol(8),tetrahydroharmol(9),harmindolβ-D-glucopyranoside(10),tryptophylβ-D-glucopyranoside (11),pegamineβ-D-glucopyranoside (12),vasicol (13)和vasicinone(14)。其中化合物1为新化合物,2和10是2个新天然产物。

To investigate the N-containing compounds in the seeds of Paganum harmala,fourteen compounds were finally isolated from the 95%Et OH extract of P.harmala seeds by using various chromatographic techniques including silica gel,MCI resin,and ODS column chromatography as well as the semi-preparative HPLC.Depending on spectroscopic techniques and comparison with the reported data in the literatures,the structures of all compounds were identified as N-[3-(2-amino-4-methoxyphenyl)-3-oxopropyl]acetamide(1),dehydroharmalacidine(2),harmalacidine(3),harmine N-oxide(4),harmine(5),tetrahydroharmine(6),demethylharmalacidine(7),harmol(8),tetrahydroharmol(9),harmindolβ-D-glucopyranoside(10),tryptophylβ-D-glucopyranoside(11),pegamineβ-D-glucopyranoside(12),vasicol(13)and vasicinone(14).Among them,1 was a new compound,and 2 and 10 were obtained as natural products for the first time.