摘要
通过各种色谱技术,对柳叶拟沉香中的化学成分进行分离,并根据波谱数据结合理化性质共鉴定了2个倍半萜类化合物,分别为12-hydroxy-dihydrocyperolone (1)和(rel)-4β,5β,7β-eremophil-9-en-12,8α-olide (2),其中化合物1是新化合物。活性测试结果显示化合物2对人慢性髓原白血病细胞株K562和人肝癌细胞株BEL-7401具有一定的细胞毒活性,其IC50分别为(17.85±0.04),(21.82±0.07)mg·L-1[紫杉醇为阳性对照,IC50分别为(1.97±0.11),(6.31±0.08) mg·L-1]。
Two sesquiterpenes were isolated from the agarwood originating from Gyrinops salicifolia with various chromatographic techniques,and their structures were determined as 12-hydroxy-dihydrocyperolone(1)and(rel)-4β,5β,7β-eremophil-9-en-12,8α-olide(2),through a combined analysis of physicochemical properties and spectroscopic evidence.Compound 1 was a new compound.Compound 2 showed cytotoxicities against K562 and BEL-7401 cell lines,with IC50 values of(17.85±0.04)and(21.82±0.07)mg·L-1,respectively[taxol as positive control,with IC50 values of(1.97±0.11)and(6.31±0.08)mg·L-1].
作者
陈惠琴
郭丰娟
蔡彩虹
董文化
王昊
李薇
梅文莉
戴好富
CHEN Hui-qin;GUO Feng-juan;CAI Cai-hong;DONG Wen-hua;WANG Hao;LI Wei;MEI Wen-li;DAI Hao-fu(Bioscience and Biotechnology,Chinese Academy of Tropical Agricultural Sciences,Haikou571101,China;Hainan Key Laboratory for Research and Development of Natural Products from Li Folk Medicine,Haikou571101,China;Hainan Engineering Research Center of Agarwood,Haikou571101,China)
出处
《中国中药杂志》
CAS
CSCD
北大核心
2019年第11期2274-2277,共4页
China Journal of Chinese Materia Medica
基金
海南自然科学基金创新研究团队项目(2017CXTD020)
现代农业产业技术体系建设专项(CARS-21)
中国热带农业科学院院级创新团队南药产业技术创新团队项目(17CXTD-15)
关键词
柳叶拟沉香
倍半萜
细胞毒活性
Gyrinops salicifolia
sesquiterpene
cytotoxicity
