中药“炒炭存性”炮制共性技术的研究现状及超分子“印迹模板”表征技术的提出

Research status of common processing technology of traditional Chinese medicine "maintaining medicinal properties after carbonisatus" and supramolecular "imprinting template" characterization technology

运用中药生物超分子体特征和'印迹模板'作用规律,分析中药炮制'炒炭存性'研究现状及共性问题,并提出破解之策。根据中药炮制'炒炭存性'的历史沿革,运用生物超分子化学理论,阐明其共性问题的根源。中药为巨复生物超分子体,中药炮制就是对生物超分子体的炮制,其本质是在外界高温、高湿条件下,加辅料与不加辅料对生物超分子主客体进行化学变化的中药制药技术。中药'炒炭存性'炒的是主体分子,存的是客体分子,主客体分子的变化规律受控于'印迹模板',反映到饮片药性与药效的变化程度上。超分子化学贯穿始终,可通过超分子拓扑结构特征和印迹行为来表征炭药的'印迹模板'作用规律,并结合定量的炮制火候数学模型,从源头上实现'炒炭存性'的精确炮制,定量控制炭药饮片质量,制订出稳定可控的质量标准。

Based on the characteristics of biological supramolecules and the law of'imprinting template',the research status and common problems in'maintaining medicinal properties after carbonisatus'in traditional Chinese medicine(TCM)were analyzed,and the further countermeasures were put forward.According to the historical evolution of'maintaining medicinal properties after carbonisatus'in TCM processing,the origin of its common problems was clarified by using the theory of biosupramolecular chemistry.TCM is a megacomplex biological supramolecular system,so TCM processing is just the processing of megacomplex biological supramolecular system,and its essence is a TCM pharmaceutical technology with chemical changes in host and guest of biological supramolecular system with or without adjuvant material under high temperature and humidity.In this study on pharmaceutical technology,host molecule was destructed in the process of carbonizing,but guest molecule was retained.The changing law of the host and guest molecule was controlled by the'imprinting template',which was reflected in the degree of change in the drug properties and efficacy of the decoction pieces.Supramolecular chemistry ran through the whole process,and the'imprinting template'of charcoal medicine was characterized by the supramolecular topological structure characteristics and imprinting behavior.After being combined with the quantitative mathematical model of heating degree in processing,it can realize the accurate processing of'maintaining medicinal properties after carbonisatus'from the source,quantitatively control the quality of carbonic herbs,and formulate stable and controllable quality standards.