烟酸缺乏症1例及文献复习

One case with pellagra and Litereture Review

患者,女,63岁,颜面、双手背及双足背起红斑、水疱、糜烂及皲裂2周。皮损初起为水肿性潮红斑、水疱、糜烂,之后色泽变暗褐色,呈大片焦痂状,不久皮损肥厚,颜色变暗黑色,呈粗糙无弹性的黑色痂盖及皲裂。组织病理示:表皮角化过度,表皮不规则萎缩、灶性基层液化,真皮浅层水肿,可见色素颗粒及嗜酸性粒细胞,血管周围少量的淋巴细胞浸润。诊断:烟酸缺乏症。本文就其病因、临床表现、组织病理和治疗进行了文献复习。

One patient,aged 63 yers old.Face,hands,and feet on her own back erythema,blisters,erosions and chapped two weeks.Early lesions of edema tide erythema,blisters,erosions,and then become dark brown color,showing large areas of eschar-like,soon,hyperfrophic lesions,dark color change,was rough inelasric black scab cover and chapped.Histopathology showed:epidermal hyperkeratosis,irregular epidermal atrophy,focal primary liquefaction,dermal edema,visible pigment granules and eosinophils,perivascular infiltration of small lymphocytes.Pellagra was diagnosed.Its etionlogy,clinical manifestations,pathophysiology and treatment were reviewed.