小剂量氨茶碱联合布地奈德治疗中重度慢性阻塞性肺疾病稳定期患者的疗效

Moderate to severe chronic obstructive pulmonary disease patients with stable efficacy in the small dose of aminophylline budesonide treatment

目的:观察探讨小剂量氨茶碱联合布地奈德治疗中重度慢性阻塞性肺疾病稳定期患者的临床疗效,总结其临床应用价值。方法:选取我院2009年4月至2011年4月中重度慢性阻塞性肺疾病稳定期的患者64例,随机分为观察组和对照组,各32例,观察组使用小剂量氨茶碱联合布地奈德治疗;对照组单纯使用布地奈德治疗,观察比较两组治疗效果,进行统计学分析。结果:观察组显效19例,有效10例,无效3例,不良反应2例,总有效率为90.7%;对照组显效13例,有效9例,无效10例,不良反应1例,总有效率为68.8%,两组疗效比较差异显著(P【0.05),具有统计学意义;两组不良反应比较无显著差异(P】0.05),无统计学意义。结论:小剂量氨茶碱联合布地奈德治疗中重度慢性阻塞性肺疾病稳定期患者的临床疗效显著,明显优于单纯使用布地奈德治疗,能够有效缓解临床症状,改善肺功能,不良反应少,安全可靠,值得临床上合理推广应用。

Objective:To observe the clinical efficacy,explore dose aminophylline Budesonide treatment of moderate to severe chronic obstructive pulmonary disease patients with stable summary of its clinical value.Methods:64 cases of our hospital from April to mid-April 2011 with severe chronic obstructive pulmonary disease stability of the patients were randomly divided into observation group and control group,32 cases in the observation group to use a small dose of aminophylline Budesonide treatment;control group were treated with budesonide therapy,observed treatment effects were compared and analyzed statistically.Results:The 19 cases markedly effective in 10 cases,3 cases,2 cases of adverse reactions,the total effective rate was 90.7%;control group of 13 patients were markedly effective in 9 cases,10 cases were ineffective,one cases of adverse reactions,the total effective rate 68.8% of two groups the difference was significantly(P<0.05),with statistical significance;two sets of adverse reactions was no significant difference(P>0.05),no significant.Conclusion:The clinical efficacy of small doses of aminophylline Budesonide treatment of moderate to severe chronic obstructive pulmonary disease patients with stable,significantly better than that of budesonide therapy can effectively relieve symptoms,improve lung function,fewer adverse reactions,safe and reliable,it is worth to promote the use of reasonable clinical.