阿托伐他汀治疗高脂血症的临床观察

目的观察阿托伐他汀治疗高脂血症的临床效果和安全性。方法选择80例总胆固醇(TC)≥6.5mmol/L或甘油三酯(TC)≥1.7mmol/L或高密度脂蛋白胆固醇(HDL-C)≤1.3mmol/L患者给予阿托伐他汀20mg/d,晚间顿服,均治疗12周,12周后分别测定血脂四项,血常规、肝、肾功能,谷丙转氨酶(ALT),肌酸磷酸激酶(CK)等。结果治疗前后血脂有显著变化,改善血TC、TG、LDL-C的总有效率分别为96.8%、71.4%、67%未发现明显不良反应。结论阿托伐他汀治疗高脂血症效果显著,对心脑血管疾病有预防作用。

Objective To observe the effeef and safety of treament of hyperlipidemia with atorvastatin.Methods 80 patients with total cholesterol(TC)≥6.5mmol/L or triglyceride(TG)≥1.7mmol/L or high density lipoprotein cholesterol(HDL-C)≤1.3mmol/L were selected.Atorvastatin 20mg were given everyday.At 12 weeks the four lipids、blood liver and kidney、function、alanine aminotransferase(ALT)creatinekinase(CK)were,measured.Results Before and after treament significant changes in blood lipids.total affective rate of improving blood TC、TG、LPL-C.96.8%、71.4%、67% respetively.No significant adverse drug reactions were found.Conclusion The effect of ator vastatin be treated for hyperlipidemia is significant.Less side effects.it’s meaningful for preventing cardiovascular daisease