药物联合应用治疗胃炎及胃十二指肠溃疡临床疗效观察

Clinical curative effect observation on gastritis and gastroduodenal ulcer in the treatment with combination drug

目的探讨药物联合应用治疗胃炎及胃十二指肠溃疡临床疗效。方法选取本院2009年10月-2011年12月收治的胃炎及胃十二指肠溃疡患者136例,随机分为两组,采用雷尼替丁(口服150mg/次,2次/d)、阿莫西林(口服250mg/次,3次/d)治疗患者68例为对照组;采用雷尼替丁、小建中片(口服180mg/次,3次/d)、阿莫西林治疗患者68例为观察组,疗程均为两周,比较两组患者治疗后的临床疗效。结果观察组总有效率(95.6%)明显高于对照组(85.3%),观察组不良反应发生率(5.9%)明显低于对照组(17.6%),差异有统计学意义(p【0.05)。结论药物联合应用治疗胃炎及胃十二指肠溃疡具有显著的临床疗效,可以明显改善患者的临床症状,提高治愈率且安全可靠,值得临床推广使用。

Objective To investigate the clinical efficacy on gastritis and gastroduodenal ulcer in the treatment with combination drug.Methods 136 patients with gastritis or gastroduodenal ulcer were selected in the hospital from October 2009 to December 2011,who were randomly divided into two groups. 68 patients used ranitidine ( oral150mg/time,2times/d) ,amoxicillin ( oral250mg/time,3times/d) in the treatment as the control group. 68 patients used ranitidine,Xiaojianzhong tablet ( oral180mg/time,3times/d) ,amoxicillin in the treatment as the observation group. The course of treatment was two weeks. Clinical efficacy was compared between two groups after the treatment. Results Total effective rate in the observation group ( 95. 6% ) was significantly higher than that in the control group ( 85. 3% ) . The incidence of adverse reactions in the observation group ( 5. 9% ) was significantly lower than that in the control group ( 17. 6% ) . The difference was statistically significant ( P < 0. 05) . Conclusions Combination drug in the treatment for gastritis and gastroduodenal ulcer has obvious clinical curative effect,which can significantly improve the clinical symptoms of patients and the cure rate. That is safe and reliable,which is worthy of clinical use.