曲美他嗪治疗高血压合并糖尿病左室舒张功能不全的临床研究

目的观察曲美他嗪对高血压合并糖尿病左室舒张功能不全的改善作用。方法将58例高血压合并糖尿病左室舒张功能不全随机分为两组,分别予以基础治疗(对照组)和加用曲美他嗪(观察组),治疗12周后观察其左室射血分数(LVEF)、左室舒张末期容积(EDV)、左室收缩末期容积(ESV)以及临床疗效。结果与对照组相比,观察组能明显的提高总有效率(79.49%】69.23%),改善LVEF、EDV、ESV,进而改善高血压合并糖尿病左室舒张功能不全的临床症状。结论曲美他嗪可增加高血压合并糖尿病左室舒张功能不全心肌的收缩力,提高心排血量。

Objective To observe trimetazidine on the improvement of hypertension and diabetes left ventricular diastolic dysfunction role.Methods 58 cases of hypertension and diabetes left ventricular diastolic dysfunction were randomly divided into two groups,respectively,be the basis of treatment(control group) and with trimetazidine(study group) was observed after 12 weeks of treatment,left ventricular ejection fraction(LVEF),left ventricular end-diastolic volume(EDV),left ventricular contraction to the end of the volume(ESV),and clinical efficacy.Results compared with the control group,the observation group can significantly improve the overall efficiency(79.49% vs.69.23%),improve LVEF,EDV and ESV,thereby improving the clinical symptoms of hypertension and diabetes left ventricular diastolic dysfunction.Conclusion Trimetazidine triazine can increase the treatment hypertension and diabetes left ventricular diastolic dysfunction,myocardial contractility and improve cardiac output and improve clinical symptoms.