肺癌患者血清CEA、NSE、CYFRA-21-1放射免疫检测与骨扫描联合诊断骨转移的应用价值

The value of detecting serum tumor marker in the diagnosis bone metastasis in lung cancer

目的探讨血清肿瘤标志物水平对提高骨扫描对肺癌骨转移诊断准确率的临床价值。方法放射免疫分析法(RIA)检测50例原发性肺癌血清CEA、NSE、CYFRA-21-1水平,并与核素骨扫描结果进行对比,应用统计学方法进行分析。结果单纯骨扫描诊断骨转移的特异性为75%,假阳性率为25%。骨转移组的CEA、NSE、CYFRA-21-1血清水平均高于骨未转移组(p【0.05)。结论肺癌骨转移患者CEA、NSE、CYFRA-21-1血清学水平明显增高,检测这些肿瘤标志物有助于提高核素骨扫描诊断肺癌骨转移的特异性。

Objective The purpose is to analyze the value of detecting serum tumor marker in the diagnosis bone metastasis in lung cancer.Methods The serum CEA,NSE,CYFR-21-1 of 50 lung cancer patients were detected with radio-immunoassay.At one time,whole-body bone scanning was detected in same patient.The result was analysed by statistical methods.Results The specificity of whole-body bone scanning is 75%,and the false positive rate is 25%.The consistence of serum CEA,NSE,CYFR-21-1 of lung cancer patients with bone metastasisare obviously higher than patients without bone metastasis.Conclusion whole-body bone scanning associating with tumor marker can improve the specificity of diagnosis in bone metastases.