乳腺癌中金属硫蛋白的表达及与其与配对淋巴结转移的关系

Metallothionein expression in breast cancer and their paired lymph node metastasis in

目的探讨金属硫蛋白在乳腺浸润性导管癌中的表达及与淋巴结转移的关系。方法用免疫组化s—P法检测乳腺癌及人正常乳腺组织中金属硫蛋白的表达。结果金属硫蛋白在正常乳腺组织几乎不表达,在乳腺癌中的阳性表达阳性率为73.0%;金属硫蛋白在有淋巴结转移组和无淋巴结转移组的阳性率分别为55.2%和13.2%(P【0.05),有统计学意义。结论金属硫蛋白在乳腺癌中表达增高,且同乳腺癌淋巴结转移相关,提示有促进乳腺癌发生、发展的可能。

Objective To investigate the metal sulfur protein in breast invasive ductal carcinoma and its relationship with lymph node metastasis.Methods Using immunohistochemical s-P method for detection of breast cancer and normal breast tissue expression of metallothionein.Results Metallothionein in normal breast tissue was not expressed in breast cancer,the expression positive rate was 73%;of metallothionein in the cases with lymph node metastasis and no lymph node metastasis group the positive rates were 55.2% and 13.2%(P<0.05),with statistical significance.Conclusion Metallothionein expression in breast cancer is increased,and the lymph node metastasis of breast cancer related,suggesting to promote breast cancer occurrence,development potential.