血管紧张素转换酶基因多态性与慢性心力衰竭的发生及转归被引量：1

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摘要目的探讨中国南方汉族人群中,血管紧张素转换酶(ACE)基因多态性与慢性心力衰竭(CHF)发病及转归的关系。方法应用聚合酶链反应技术测定111例CHF患者和110例健康者的ACE基因I/D多态性。结果①CHF组DD基因型与D等位基因的频率均高于对照组(DD基因型:0.468比0.227,P【0.01;D等位基因:0.667比0.436,P【0.01)。②病例组中,左室舒张末期内径(LVDD)DD】ID】II(P【0.05)心功能2级的例数占II型总例数的40.0%,心功能4级的占13.3%,DD型CHF患者中,心功能2级的例数占DD型总例数的13.3%,心功能4级的占35.0%,差别有显著性(P=0.014)。结论 ACE基因I/D多态性与中国南方部分汉族人群CHF的发生及不良转归相关,ACE-DD型可能是该地区CHF发病的遗传危险因素;ACE基因多态性与CHF病情严重程度的关联强度依次为为:DD】ID】II。

作者梅啸黄远贞袁海燕

机构地区广州医学院第四附属医院心内科珠海市第二人民医院ICU

出处《中国保健营养（下半月）》 2012年第9期3661-3662,共2页 China Health Care & Nutrition

关键词血管紧张素转换酶基因多态性心力衰竭转归

分类号 R541.6 [医药卫生—心血管疾病]

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