原发性胆汁性肝硬化临床诊治分析

Primary biliary cirrhosis of liver clinical analysis

目的分析原发性胆汁性肝硬化患者的临床特征,通过临床特征的分析以提高对原发性胆汁性肝硬化的认识。方法将2008年06月-2011年07月收治的400例患者进行临床患者的资料分析总结,观察该组患者的一般资料、病程以及临床表现等,将获得的患者数据进行分析。结果本组患者共有400例,确诊时的平均年龄为52.4岁±6.2岁,患者的临床表现主要有乏力、黄疸、皮肤瘙痒等。其中本组患者中表现为乏力现象的有120例,占该组患者的30%,表现为黄疸的有75例,占该组患者的18.8%;皮肤瘙痒现象的有130例,占患者总数的32.5%。本组患者中临床表现占两种以上的有60例,占该组患者的15%。8例患者无明显临床表现,7例患者合并有其他自身免疫性疾病,占该组患者的3.75%。该组患者均经过检测结果显示碱性磷酸酶以及r谷氨酰转肽酶数值升高,110例患者的胆红素均有不同程度的身高,90例患者的血清值升高,有310例患者的患者抗线粒体抗体呈现阳性。本组患者中有290例患者采取肝穿刺病理检测,早期患者占88.5%,晚期患者占到11.5%。结论原发性胆汁性肝硬化患者一般为中年女性,其临床主要表现是皮肤瘙痒、乏力、黄疸等,患者的碱性磷酸酶以及r谷氨酰转肽酶等水平升高,血清值也升高。诊断原发性胆汁性肝硬化患者应当及早诊断,实现及早治疗。临床中采用抗线粒体抗体阳性,特别是以M2阳性对原发性胆汁性肝硬化患者具有良好诊断功能。

Objective Analysis of patients with primary biliary cirrhosis:clinical characteristics,through the analysis of the clinical characteristics of primary biliary cirrhosis awareness.Methods In 2008 06 from January to 2011 07 400 cases of patients with clinical data analysis summary,observed in this group of patients,general information,course of disease and clinical manifestation,will receive patient data analysis.Results In this group of patients with a total of 400 patients,diagnosed at a mean age of 52.4 years old-6.2 years old,with the main clinical manifestations of fatigue,jaundice,pruritus,etc.One of the groups of patients appears weak phenomenon in 120 cases,accounting for the group in 30%,showed jaundice 75 cases,accounting for the group of patients with skin pruritus phenomenon of 18.8%;in 130 cases,accounting for 32.5% of the total number of patients.This group of patients in clinical presentation accounted for more than two of the 60 cases,accounting for the group of patients with 15%.In 8 patients without obvious clinical manifestations,7 patients with other autoimmune diseases,accounting for the group of patients with 3.75%.The patients were tested the results showed alkaline phosphatase and R glutamyltransferase numerical elevated bilirubin,110 patients had different degrees of height,90 cases of patients with elevated serum levels,310 patients had antimitochondrial antibody positive patients.This group of patients in 290 patients by liver biopsy pathology detection,early patients accounted for 88.5%,11.5% patients with advanced standing.Conclusion Primary biliary cirrhosis patients are typically middle-aged women,its main clinical manifestation is pruritus,jaundice,fatigue,patients with alkaline phosphatase and R glutamyltransferase and elevated levels of serum values were also elevated.The diagnosis of primary biliary cirrhosis patients should be early diagnosis,early treatment to realize.Clinical use of antimitochondrial antibody positive,especially with M2 positive for primary biliary cirrhosis patients with good diagnostic function.