帕瑞昔布钠联合舒芬太尼在下肢骨科手术镇痛的研究

Study of parecoxib sodium with sufentanil in analgesia for lower limb orthopedic surgery

目的探讨下肢骨科患者术后应用帕瑞昔布钠、舒芬太尼联合镇痛的临床疗效。方法随机将腰硬联合麻醉的62例下肢骨折患者分为观察组30例、对照组32例,两组术后均给予舒芬太尼自控镇痛,观察组在该镇痛基础上另于术毕给予帕瑞昔布钠静脉滴注。结果观察组术后8h、24hVAS评分均明显低于对照组(P【0.05),观察组术后24h舒芬太尼总用量明显少于对照组(P【0.05),两组不良反应情况比较无显著差异(P】0.05)。结论帕瑞昔布钠在下肢骨折患者术后镇痛上疗效显著,帕瑞昔布钠、舒芬太尼联合用药是一种有效的骨折术后镇痛用药方法。

Objective To investigate the clinical efficacy of parecoxib sodium with sufentanil in analgesia for the lower extremity orthopedic surgery.Methods 62 patients with lower extremity fractures for lumbar epidural anesthesia randomly divided into observation group of 30 patients and control group of 32 patients.Patients in the two groups were given sufentanil after surgery controlled,and patients in the observation group were given parecoxib sodium on the basis of sufentanil for analgesia.Results Scores of 8h and 24h VAS were significantly lower in the observation group than the control group(P <0.05).Total amount of sufentanil about 24h after surgery was significantly less in the observation group than the control group(P < 0.05).There was no difference about adverse reactions in two groups(P > 0.05).Conclusion Parecoxib sodium has significant effect on postoperative analgesia in patients with lower extremity fractures.Parecoxib sodium combination with sufentanil is an effective method for postoperative analgesia in patients with lower extremity fractures.