辛伐他汀对高血压病合并2型糖尿病患者血脂水平、颈动脉粥样硬化的影响

Simvastatin on lipid levels,carotid artery atherosclerosis in patients with hypertension and type 2 diabetes

目的探讨辛伐他汀对高血压病合并2型糖尿病患者血脂水平、颈动脉粥样硬化的影响。方法将96例高血压病合并2型糖尿病患者随机分为基础治疗组(对照组)和辛伐他汀+基础治疗组(治疗组),两组患者均给予控制血压、血糖的基础治疗,而治疗组患者在基础治疗的基础上同时给予辛伐他汀,观察周期为6个月。治疗前后用彩色多普勒超声检测颈动脉内膜-中膜厚度(IMT),并且测定患者血脂水平,在治疗过程中观察血压、肝功等。结果治疗前两组患者的总体血压水平、空腹血糖水平、颈动脉内膜-中膜厚度无显著差异,P】0.05;在治疗6个月后,治疗组治疗后与治疗前比较,治疗组与对照组比较,治疗组患者的甘油三酯、总胆固醇、低密度脂蛋白、载脂蛋白B、载脂蛋白B/载脂蛋白A1、颈动脉内膜-中膜厚度均显著降低,而高密度脂蛋白、载脂蛋白A1明显增高,均P【0.05;而对照组患者治疗前后无显著性差异,P】0.05。结论对于高血压病合并2型糖尿病患者,血压、血糖异常和脂代谢异常,更易发生血管并发症,在有效控制血压、血糖水平基础上,还要注重调脂治疗,辛伐他汀可有效地调整血脂水平,能明显减轻颈动脉粥样硬化病变,可作为高血压病合并2型糖尿病患者预防或延缓颈动脉粥样硬化的常规用药。

Objective To investigate Simvastatin on lipid levels,carotid atherosclerosis in patients with hypertension and type 2 diabetes mellitus.Methods 96 patients with hypertension and type 2 diabetes patients were randomly divided into a the foundation treatment group(control group)and simvastatin + basic treatment group(treatment group),the two groups of patients were given control of blood pressure,blood sugar basic treatment and treatment group of patients in the basic treatment at the same time give simvastatin,the observation period of 6 months.Before and after treatment with color Doppler ultrasound carotid intima-media thickness(IMT),determination of blood lipid levels and blood pressure,liver function was observed in the course of treatment.Results Before treatment,the overall level of blood pressure,fasting glucose levels,carotid intima-media thickness no significant difference(P> 0.05);After 6 months of treatment,the treatment group after treatment compared with before treatment,the treatment group control group,patients treated with triglycerides,total cholesterol,low-density lipoprotein,apolipoprotein B,apolipoprotein B/apolipoprotein A1,carotid intima-media thickness were significantly lower,and the high density lipoprotein,apolipoprotein A1 was significantly higher,both P<0.05;while the control group patients showed no significant difference(P>0.05).Conclusion For patients with type 2 diabetes in patients with hypertension,blood pressure,glucose and lipid abnormalities more susceptible to vascular complications,in effective control of blood pressure,blood sugar levels on the basis of lipid lowering therapy,but also pay attention to simvastatin can effectively adjust lipid levels can be significantly reduced atherosclerotic lesions in the carotid artery,as hypertensive patients with type 2 diabetes to prevent or delay the hardening of conventional medication carotid atherosclerosis.