康艾注射液联合维生B6防治卡培他滨所致手足征的临床观察

Kangai injection combined with vitamin B6 prevention capecitabine-induced hand-foot-levy clinical observation

目的观察康艾注射液联合大剂量维生素B6防治卡培他滨化疗所致手足综合征的效果。方法 38例肿瘤患者采用卡培他滨联合化疗,预防治疗组于化疗前3天给予口服维生素B6300mg/d,联合康艾注射液静脉滴注至化疗结束;对照组仅给予口服维生素B6300mg/d。结果预防治疗组手足综合征发生率为31.58%,且反应轻,无IV度者;对照组手足综合征发生率为57.89%,其中III度者26.32%。预防组手足综合征发生率明显低于对照组,差异有统计学意义(P【0.05),且程度轻。结论康艾注射液联合大剂量维生素B6预防卡培他滨所至手足综合征疗效确定,是较理想的预防治疗方案。

Objective Concept Cha Kangai injection combined with large doses of vitamin B6 prevention capecitabine chemotherapy-induced hand-foot syndrome effect. Methods 38 patients with cancer capecitabine combination chemotherapy,preventive treatment group given oral vitamin B6 300mg / d,three days before chemotherapy joint Kangai intravenous injection to the end of chemotherapy; control group were given oral vitamin B6 300mg /d. Results The prevention treatment group hand-foot syndrome occurred was 31. 58% and the reaction to light,IV degree; hand-foot syndrome of the control group was 57. 89% ,including 26. 32% of III degree. Hand-foot syndrome prevention group were significantly lower than the control group,the difference was statistically significant( P < 0. 05) ,and to a lesser degree. Conclusion The Kangai injection combined with large doses of vitamin B6 prevent the capecitabine Suozhi hand,foot syndrome to determine better prevention and treatment programs.