低体重儿胃肠外营养相关性胆汁淤积的初步研究

The preliminary study of the parenteral nutrition associated cholestasis in low birth weight children

目的本研究旨在探讨胃肠外营养与胃肠外营养相关性胆汁淤积(PNAC)发生相关的危险因素,为该病的预防提供临床依据。方法采用外周静脉持续均匀输注营养液。同时在病情允许下给予微量喂养从少到多添加奶量,逐渐过渡到肠道内营养。所有低出生体重儿均在胃肠外营养停止后测定肝功能。结果长期大剂量输注胃肠外营养是导致PNAC高危危因素。结论胎龄越小,全静脉营养时间越长、PN持续时间越长,越易发生PNAC。尽早肠内喂养,缩短PN时间,是降低PNAC的重要措施。

Objective The purpose of this study is to explore parenteral nutrition and parenteral nutrition associated cholestasis(PNAC)the risk factors associated,Clinical basis for disease prevention.Methods Uniform continuous intravenous infusion of peripheral nutrient solution.Add the milk from less to more I feedings in a condition to allow,A gradual transition to enteral nutrition.All low-birth-weight children were measured liver function after the stop of parenteral nutrition.Results The long-term high-dose infusion of parenteral nutrition lead PNAC high risk of danger factors.Conclusion Smaller the gestational age,The longer total parenteral nutrition,More prone PNAC,Enteral feeding as soon as possible to shorten the PN time,is to reduce the PNAC.