持续小剂量静脉滴注奥美拉唑治疗新生儿应激性溃疡的疗效

Effect of Continuous ulcer of small dose of Omeprazole in Treating Neonatal Irritability

目的探讨分析持续小剂量静脉滴注奥美拉唑治疗新生儿应激性溃疡的疗效。方法选取我院2011年1月——2011年12月间收治的80例新生儿应激性溃疡患儿,随机分为观察组和对照组,每组患儿各40例。观察组在综合治疗的基础上给予奥美拉唑(2mg/kg)2mg/kg,24小时持续小剂量静脉滴注。对照组在综合治疗的检查上给予奥美拉唑(0.8mg/kg·d),1次/天,连续使用3天。比较两组的治疗效果。结果观察组显效率为95%(38/40),平均止血时间为1.02±0.04天,对照组显效率为47.5%(19/40),平均止血时间为2.09±0.95天,两组比较,P【0.05具有显著性差异,有统计学意义;观察组用药后胃液pH值升高且保持稳定,两组患儿用药后血压、心率、呼吸无明显变化,两组患儿用药过程中未有明显不良反应发生。结论持续小剂量静脉滴注奥美拉唑治疗新生儿应激性溃疡的疗效显著,值得临床推广。

Objective To investigate the clinical efficacy of continuous ulcer low - dose intravenous infusion of omeprazole in treating neonatal irritability. Methods In our hospital in 2011 January ——2011 year in December admitted 80 cases of neonatal stress ulcer in children,were randomly divided into observation group and con- trol group,each group with 40 cases in each. The observation group was treated on the given omeprazole( 2mg‘kg) 2 mg‘kg,24 hours of continuous low - dose intrave- nous drip. The control group was treated with omeprazole( 0. 8mg‘kg test,d) ,1 time / day,3 days of continuous use. Therapeutic effect comparison between the two groups showed a significant. Results The observation group was 95% ( 38‘40) ,average hemostasis time was 1. 02 ± 0. 04 days,the control group was 47. 5% ( 19‘40) , average hemostasis time was 2. 09 ± 0. 95 days,the two groups,P < 0. 05 has significant difference,there is statistical significance; the observation group after treatment, gastric fluid pH value rise and remain stable,use two groups after blood pressure,heart rate,respiration did not change significantly,no significant adverse reactions oc- curred in two patients during the treatment. Conclusion The curative effect of continuous intravenous infusion of small dose of ulcer omeprazole in the treatment of neo- natal stress significantly,worthy of clinical application.