探讨川芎嗪联合头孢抗生素治疗老年慢性支气管炎急性发作的临床效果

Objective to Investigate the Clinical Effect of Ligustrazine Combined with Antibiotics in the Treatment of Elderly Patients with Acute Exacerbation of Chronic bronchitis

目的探讨川芎嗪联合头孢抗生素治疗老年慢性支气管炎急性发作的临床效果。方法随机筛选出我院在2013年3月-2016年10月期间收治的150例老年慢性支气管炎急性发作患者作为研究对象,采用奇偶分组法分为对照组和观察组,每组各75例。对照组患者单独采用头孢抗生素治疗,观察组患者则在此基础上联合川芎嗪治疗。对比两组患者临床治疗效果和退热、咳嗽消失、肺部阳性体征消失时间,并将两组患者治疗前后白细胞总数和中性粒细胞百分数进行比较。结果观察组患者临床治疗总有效率较高,与对照组患者相比,差异显著(P<0.05);且观察组患者退热、咳嗽、肺部阳性体征消失时间均比对照组短,差异有统计学意义(P<0.05);治疗前两组患者白细胞总数和中性粒细胞百分数比较,差异均无统计学意义(P>0.05),治疗后两组患者以上两项指标均比治疗前低,差异显著(P<0.05),且治疗后观察组患者白细胞总数和中性粒细胞百分数均明显低于对照组,差异显著(P<0.05)。结论老年慢性支气管炎急性发作采用川芎嗪联合头孢抗生素治疗可在短时间内改善患者临床症状,获得满意的治疗效果,值得在临床医学中推广与应用。

Objective To investigate the clinical effect of treatment of senile chronic bronchitis in acute attack of Ligustrazine Combined with cephalosporin antibiotics.Methods Randomly selected in our hospital during March 2013-October 2016 150 cases of acute attack of senile chronic bronchitis patients as the research object,divided into the observation group and the control group by parity grouping method,75 cases in each group.The patients in the control group used alone cephalosporin antibiotic therapy,patients in the observation group on the basis of Ligustrazine.Compared two groups of patients with clinical curative effect and fever,cough,positive lung signs disappeared time,and two groups of patients before and after the total white blood cell count and neutrophil percentage were compared.Results The clinical observation of patients have higher efficiency and compared with the control group,the difference was significant(P<0.05);and the patients in the observation group of fever,cough disappeared,positive lung signs disappeared time were shorter than the control group,the difference was statistically significant(P<0.05);the total number of patients in the two groups of white blood cells and percentage of neutrophils compared with before treatment,there were no significant differences(P>0.05),two groups after the treatment,the two indexes above were lower than before treatment,the difference was significant(P<0.05) after treatment,and the observation group of white blood cell count and neutrophil percentage were significantly lower than the control group,the difference was significant(P<0.05).Conclusion The Ligustrazine Combined with antibiotic therapy can improve the clinical symptoms of patients in a short period of time of acute attack of senile chronic bronchitis,obtain satisfactory curative effect,worthy of promotion in clinical medicine with the application.