胺碘酮治疗急性心肌梗死合并心房颤动的临床分析

Clinical Analysis of Amiodarone in the Treatment of Patients with Acute Myocardial Infarction Complicated with Atrial Fibrillation

目的评价胺碘酮在急性心肌梗死合并心房颤动中的应用价值。方法研究对象取160例我院收治的急性心肌梗死合并心房颤动患者,患者均于2015年1月份到2016年12月份入院治疗。随机分组,对照组采用普罗帕酮进行治疗,共80例患者;实验组采用胺碘酮进行治疗,共80例患者。观察患者的治疗情况,并对其进行分析和比较。结果 (1)两组患者治疗效果比较:实验组的总有效率为97.5%(78/80),对照组的总有效率为76.3%(61/80),实验组的总有效率高于对照组,数据差异性明显,P<0.05;(2)患者不良反应比较:实验组的恶心呕吐、血压下降、心动过速、房室传导阻滞率均低于对照组,实验组的不良反应率比对照组低,数据差异性明显,P<0.05;(3)患者24h心房颤动转复情况比较:实验组6h、6-12h、12-18h、18-24h的心房颤动转复率均比对照组低,实验组患者24h内心房颤动转复率比对照组高,组间数据差异性明显,有统计学意义,P<0.05。结论应用胺碘酮对急性心肌梗死合并心房颤动患者进行治疗,能够改善患者疾病症状,且安全性好,值得推荐。

Objective To evaluate the clinical value of amiodarone in patients with acute myocardial infarction complicated with atrial fibrillation. Methods 160 patients with acute myocardial infarction complicated with atrial fibrillation were enrolled in our hospital. The patients in the control group were treated with propafenone, a total of 80 patients, the experimental group was treated with amiodarone, a total of 80 patients. Observation of the treatment of patients, and its analysis and comparison. Results(1) comparing the efficacy of two groups: the experimental group total effective rate was 97.5%(78/80), the control group total effective rate was 76.3%(61/80), the experimental group was higher than that in the control group, the data have obvious difference, P<0.05;(2) comparison of the adverse reactions of patients in experimental group: the nausea and vomiting, hypotension, tachycardia, atrioventricular block rate was lower than the control group, the adverse reaction rate of the experimental group lower than the control group, the data have obvious difference,P<0.05;(3) 24 h in patients with atrial fibrillation cardioversion were compared: the experimental group 6H, 6-12 h, 12-18 h, 18-24 h conversion of atrial fibrillation the rate is lower than that of control group, experimental group 24 h in patients with atrial fibrillation cardioversion rate is higher than the control group, groups of data have obvious difference, with statistical significance, P<0.05. Conclusion Amiodarone in the treatment of patients with acute myocardial infarction complicated with atrial fibrillation, can improve the symptoms of patients with good safety, it is recommended.