分析奥氮平配合牛黄宁宫片治疗难治性精神分裂症的临床疗效

Objective to Analyze the Clinical Efficacy of Olanzapine Combined with Niuhuang Tablets in the Treatment of Refractory Schizophrenia

目的研讨难治性精神分裂症患者合用奥氮平与牛黄宁宫片治疗的临床价值。方法从我院2014年12月-2016年8月选取64例难治性精神分裂症患者进行试验分析,并按随机非盲法归组(32例/组),Ⅰ组仅接受奥氮平治疗,Ⅱ组在上述给药下配合使用牛黄宁宫片治疗,观察并评估两组药物方案的临床应用情况。结果Ⅰ、Ⅱ组接受方案治疗后,临床总有效率分别达到62.5%和78.1%,比较差异显著(P<0.05)。治疗2周后,两组的PANSS总分相比基线期显著降低(P<0.05),但组间比较差异不显著(P>0.05);治疗4、8周后,Ⅱ组的PANSS总分相比Ⅰ组均显著降低,比较差异显著(P<0.05)。两组锥体外系反应、其他副反应的发生率相比,Ⅱ组低于Ⅰ组,比较差异显著(P<0.05)。结论对难治性精神分裂症患者合用奥氮平与牛黄宁宫片治疗,方案药效显著、安全性好,值得加强推广。

Objective To study the clinical value of olanzapine combined with Niuhuang Ning tablets in the treatment of refractory schizophrenia. Methods From our hospital in December 2014-2016 year in August 64 cases of patients with refractory schizophrenia were analyzed, and according to the random non blind method group(32 cases per group), one group received olanzapine treatment, group II in the administration with Niuhuang Ningong tablet treatment, observation and evaluation the clinical application of two drugs scheme. Results The total effective rate of the treatment group and the control group were 62.5% and 78.1% respectively, and the difference was significant(P<0.05).After 2 weeks of treatment,The PANSS scores of the two groups were significantly lower than baseline(P<0.05),However, there was no significant difference between groups(P>0.05); After 4 and 8 weeks,Compared with group I, the total PANSS score of group,The difference was significant(P<0.05).Extrapyramidal reaction of the two groups、The incidence of other side effects,Group II was lower than group I,The difference was significant(P<0.05).Conclusion The treatment of patients with refractory schizophrenia combined with olanzapine and Niuhuang tablets, the efficacy of the program is significant, safe, worthy of promotion.