探究早孕期NT筛查在产前诊断的临床意义

To Investigate the Clinical Significance of Early Pregnancy NT Screening in Prenatal Diagnosis

目的分析研讨早孕期NT筛查在产前诊断中的临床意义。方法采用随机抽签方式,从我院2016年1月至2016年6月期间产前诊断的孕妇中,抽取378例纳入到讨论中,378例孕妇均在早孕期接受NT检查,根据检查结果,讨论其NT切割指数,敏感度、特异度、假阳性率、阳性预测指数等,并分析早孕期NT检查在产前诊断中的价值。结果 378例孕妇均接受早孕期NT检查,结果表明共351例均为正常发育,占比为92.86%,27例发育异常,占比为7.14%。分娩后,随访到新生儿六个月时,新生儿接受儿科各项体检,378例新生儿共356例正常,占比为94.18%。NT增厚切割指数的假阳性率、阳性预测值、特异度、敏感度分析,NT厚度≥95百分位数、1.3Mo M敏感度处于最大,平均在71%,阳性预测值、特异度最大为NT≥95百分位数96.9%、13.4%。结论早孕期NT筛查在产前诊断中具有较大临床意义,可让医生明确染色体是否异常,并排除中孕期早期超声扫描结构异常等,应用性较大。

Objective To study the clinical significance of NT screening in early pregnancy in prenatal diagnosis. Methods by random draw, from pregnant women for prenatal diagnosis in our hospital during January 2016 to June 2016, a total of 378 cases of into the discussion, 378 pregnant women underwent NT examination in early pregnancy, according to the inspection results, discussion of the NT exponent, sensitivity, specificity, false positive rate, positive predictive index. The value of NT examination and analysis of early pregnancy in prenatal diagnosis. Results All the 378 cases of pregnant women were examined by NT in early pregnancy. The results showed that all of the 351 cases were normal development, accounting for the proportion of 92.86%, abnormal development of the cases, accounting for the proportion of 7.14%. After delivery, 356 cases of newborns were followed up for up to six months after birth, and all of them received pediatric physical examination, with a total of 378 cases, accounting for 94.18%. Conclusion NT screening in early pregnancy is of great clinical significance in prenatal diagnosis. It can make the doctor to make sure whether the chromosome is abnormal, and eliminate the abnormal structure of ultrasound scanning in the early pregnancy.