试析对冠心病心绞痛患者采用参芎葡萄糖注射液治疗的临床效果

An Analysis of the Clinical Effect of Treatment of Salviae Miltiorrhizae Liguspyragine Hydrochloride and Glucose Injection in Patients with Coronary Heart Disease

目的研讨冠心病心绞痛(CHD-AP)患者实施参芎葡萄糖注射液治疗的临床药效及安全性。方法搜集2015年12月-2016年12月在我院诊疗的200例CHD-AP病例资料进行试验研究,并按随机自愿原则分组(100例/组),在常规抗凝、抗血小板药物及硝酸酯类药物等处理下,Ⅰ组接受丹参酮ⅡA磺酸钠用药,Ⅱ组接受参芎葡萄糖注射液治疗,连续2周用药后,评估及分析两组方案的中医证候疗效、心电图疗效、血液流变学指标及药物不良反应发生情况。结果Ⅱ组患者接受方案给药后,取得的中医证候、心电图总有效率各为94.0%和87.0%,相比Ⅰ组患者的75.0%和68.0%均显著提高,组间相比差异显著(P<0.05)。给药前,两组的血细胞比容、全血黏度及血浆比黏度等指标检测值相比,组间差异不显著(P>0.05);给药后,Ⅱ组除全血黏度外,其余几项指标检测值相比Ⅰ组均显著改善,组间差异显著(P<0.05)。两组在试验期间均未产生明显的药物不良反应。结论参芎葡萄糖注射液是治疗CHD-AP的有效药物,能够有效缓解患者的病症、改善血液流变学指标,且安全可靠,值得进一步推广。

Objective: To study the angina pectoris of coronary heart disease(CHD-AP) clinical efficacy and safety of treatment for patients with Salviae Miltiorrhizae Liguspyragine Hydrochloride and Glucose Injection. Methods: from December 2015-December 2016 was investigated in 200 patients with CHD-AP were collected in our hospital, and group randomly(100 cases/group), conventional anticoagulation, antiplatelet drugs and nitrates and other treatment, group 1 received tanshinone II A sodium sulfonate treatment, treatment group received Salviae Miltiorrhizae Liguspyragine Hydrochloride and Glucose Injection II and 2 weeks after treatment, and analysis and evaluation of curative effect, TCM syndrome of the two groups of ECG, blood rheology indexes and the incidence of drug adverse reactions. Results: in group II patients receiving scheme after administration of TCM syndromes, the total effective rate of ECG was 94% and 87%, compared with the group of 75% and 68% were significantly increased, the difference between groups were compared(P<0.05). Before treatment, two groups of hematocrit, whole blood viscosity and plasma viscosity ratio detection index value compared with no significant difference between the groups(P>0.05); group II except after administration, blood viscosity, detection of other indexes compared with group I were significantly improved, a significant difference between groups(P<0.05). The two groups had no obvious adverse drug reactions during the experimental period. Conclusion: Salviae Miltiorrhizae Liguspyragine Hydrochloride and Glucose Injection is effective in the treatment of CHD-AP patients, the patient can effectively relieve symptoms, improve blood rheology, safe and reliable, worthy of further promotion.