血清CA125和HE4联合检测在卵巢肿瘤良恶性鉴别及分型诊断中的应用价值

The Value of Combined Detection of Serum CA125 and HE4 in the Differential Diagnosis of Benign and Malignant Ovarian Tumors and Its Typing

目的研究血清糖化抗原125(CA125)和人附睾蛋白4(HE4)联合检测在卵巢肿瘤良恶性鉴别及分型诊断中的应用价值。方法选取医院2016年2月至2017年1月收治的90例卵巢恶性肿瘤患者作为A组,另选取同期80例卵巢良性肿瘤患者作为B组,80例健康人群作为C组,将3组受检人员间的血清CA125及HE4的水平进行对比,再统计不同分型间卵巢恶性肿瘤患者的血清CA125及HE4。结果 A组卵巢恶性肿瘤患者的血清HE4为(287.66±26.97)pmol/L,血清CA125为(256.44±10.97)U/ml,均高于B、C组,P<0.05,且于卵巢恶性肿瘤中,黏液型腺癌及浆液型腺癌患者的血清CA125及血清HE4的升高较为显著,与其他病理分型的卵巢恶性肿瘤具有显著差异,P<0.05,良性卵巢肿瘤患者间不同病理分型的血清CA125及HE4水平无显著差异,P>0.05。结论血清CA125和HE4联合检测对鉴别卵巢肿瘤良恶性有重大意义,且恶性肿瘤中黏液型腺癌及浆液型腺癌患者的血清CA125及血清HE4的水平明显高于其他分型,对恶性卵巢肿瘤的分型有一定应用价值。

Objective To investigate the value of combined detection of serum glycated antigen 125(CA125) and human epididymal protein 4(HE4) in the differential diagnosis of benign and malignant ovarian tumors.Methods From February 2016 to January 2017 the hospital treated 90 cases of patients with malignant ovarian tumor were selected as group A, the other 80 cases were benign ovarian tumor patients as group B, and 80 healthy subjects as group C,compared 3 groups of serum CA125 and HE4 between the level of inspection personnel, and statisticsed different serum levels of CA125 and HE4 in patients with malignant ovarian tumor type. Results The serum HE4 in patients with malignant ovarian tumors as group A was(287.66 + 26.97) pmol/L, serum CA125 was(256.44 + 10.97) U/ml,which were higher than those in group B and C, P<0.05,and in ovarian cancer, serum CA125 and serum HE4 in patients with mucinous adenocarcinoma and serous adenocarcinoma of the increase is significant, and other pathological types of ovarian malignant tumors had significant differences, P<0.05,there was no significant difference in serum CA125 and HE4 levels between benign and malignant ovarian tumors, P>0.05.Conclusion The combined detection of serum CA125 and HE4 have great significance in differentiating malignant from benign ovarian tumor, serum CA125 and serum HE4 in patients with mucinous adenocarcinoma and malignant tumors and serous adenocarcinoma was significantly higher than that of other type,it is of certain value in the classification of malignant ovarian tumors.