观察七味白术散联合葡萄糖酸锌治疗小儿轮状病毒肠炎的效果

Observation of Seven Kinds of Powder and Zinc Gluconate Combined Treatment of Infantile Rotavirus Enteritis is Effective

目的研讨小儿轮状病毒肠炎患者运用七味白术散与葡萄糖酸锌联合治疗的临床价值。方法将我院儿科2015年6月-2017年5月收治的98例轮状病毒肠炎患儿依照随机数表法归入两组试验,Ⅰ组48例单纯接受葡萄糖酸锌口服,Ⅱ组50例同时配合七味白术散治疗,观察评估两组的临床药效、各症状消失时间及肠道菌群变化情况。结果Ⅰ、Ⅱ组接受治疗后分别取得81.3%和98.0%的总有效率,Ⅱ组相对Ⅰ组高,比较差异显著(P<0.05)。Ⅱ组治疗后除呕吐症状外,发热、腹泻症状的消失时间均显著短于Ⅰ组,比较差异显著(P<0.05)。治疗前,两组粪检提示双歧杆菌、肠杆菌及乳杆菌水平基本相当,比较差异不显著(P>0.05),治疗后,Ⅱ组的双歧杆菌、乳杆菌水平均显著高于Ⅰ组,比较差异显著(P<0.05),但肠杆菌水平相比,两组差异不显著(P>0.05)。结论对轮状病毒肠炎患儿合用葡萄糖酸锌与七味白术散治疗,药效显著,各肠炎症状消失时间短,且对小儿肠道微生态有明显的调节作用,值得推广。

Objective To study the rotavirus enteritis in children with clinical value of seven kinds of powder and zinc gluconate combined therapy. Methods 98 cases of rotavirus enteritis in pediatrics in our hospital in June 2015 to May 2017 were randomly divided into two groups according to the test. Group I, 48 cases underwent zinc gluconate, group II and 50 cases with seven kinds of powder treatment, The clinical efficacy, symptom disappearance time and intestinal flora change of the two groups were observed and evaluated. Results The total effective rate was 81.3 % and 98 % respectively after treatment in group I and group II, and the group II was higher than that of group I, with a significant difference(P<0.05). Except the vomiting symptoms, the disappearance time of fever and diarrhea in group II was significantly shorter than that in group I, and the difference was significant(P<0.05). Before treatment, two groups of fecal bifidobacteria, suggesting that Enterobacter and Lactobacillus as a basic level, no significant difference(P>0.05), after treatment, group II of Bifidobacterium and lactobacillus were significantly higher than that in group I, and there was significant difference(P<0.05). Conclusion The children with rotavirus enteritis combined with zinc gluconate and seven kinds of powder treatment, and the children of the intestinal microflora has obvious regulation effect and is worthy of promotion.