地佐辛联合舒芬太尼用于子宫肌瘤切除术后病人皮下自控镇痛的效果观察

Effect Observation of Dezocine Combined with Sufentanil for Patient Controlled Subcutaneous Analgesia after Myomectomy

目的评价地佐辛联合舒芬太尼用于剖宫产术后病人皮下自控镇痛(PCSA)的效果。方法随机选择妇科子宫切除术患者110例,年龄在35-60岁,ASAⅠ-Ⅱ,随机分为两组(n=55);A组(对照组)于手术开始时给予芬太尼和氟哌利多,术后采用舒芬太尼PCSA,背景剂量:5 ml/h,负荷剂量:3 ml,锁定时间间隔:15 min,舒芬太尼背景输注速率0.06 ug/kg/h.B组(地佐辛组)术中处理同A组,术后采用地佐辛联合舒芬太尼进行皮下自控镇痛(PCSA),背景剂量:5 ml/h,负荷剂量:3 ml,锁定时间间隔:15 min,舒芬太尼背景输注速率0.03 ug/kg/h,地佐辛背景输注速率6 ug/kg/h.观察术后患者对皮下自控镇痛的满意度。结果 A、B两组比较,B组患者在术后对皮下镇痛满意度明显高于A组,且B组术后出现恶心呕吐等不良反应也较少(P<0.05)。结论地佐辛联合舒芬太尼用于子宫肌瘤切除术后皮下自控镇痛(PCSA)的效果优于单纯应用舒芬太尼的皮8下自控镇痛。

Objective To evaluate effect of dezocine combined with sufentanil for patient-controlled subcutaneous analgesia after cesarean section(PCSA) effect. Methods Choose 110 cases cesarean section patients randomly, aged 35-60, ASA Ⅰ-Ⅱ, divide them into two groups randomly(n=55); group A(control group) was treated with fentanyl and droperidol at beginning of operation, sufentanil PCSA after operation, with background dose of 5 ml/h, loading dose of 3 ml, lock time interval of 15 min, sufentanil background infusion rate of 0.06 ug/kg/h. Intraoperative treatment of B group(dezocine group) was same as group A, postoperative treatment was dezocine combined with sufentanil for patientcontrolled subcutaneous analgesia, with background dose of 5 ml/h, loading dose of 3 ml, lock time interval of 15 min, sufentanil background infusion rate of 0.03 ug/kg/h, dezocine background infusion rate of 0.06 ug/kg/h. Observe patient's satisfaction degree for PCSA 24 and 48 hours after operation. Results PCSA satisfaction degree of group B was higher than group A, group B has less postoperative side effects of nausea and vomiting(P<0.05). Conclusion Dezocine combined with sufentanil has better effect for PCSA after hysteromyomectomy than sufentanil PCSA only.