全反式维甲酸联合三氧化二砷治疗初发急性早幼粒细胞白血病78例临床分析

Clinical Analysis of All Trans Retinoic Acid Combined with Arsenic Trioxide Treating 78 Cases Primary Acute Promyelocytic Leukemia

目的探讨分析初发急性早幼粒细胞白血病患者采用全反式维甲酸联合三氧化二砷治疗的临床效果。方法随机选取2012年5月至2017年5月我院确诊的初发急性早幼粒细胞白血病患者40例,将其按照抽签的方式进行分组,分为对照组20例和实验组20例,两组患者均进行药物治疗,但是两组患者采用不同的治疗方案。对照组患者给予全反式维甲酸治疗,实验组给予全反式维甲酸联合三氧化二砷治疗,观察并分析两组初发急性早幼粒细胞白血病患者的临床效果,就两组患者的症状完全缓解率、症状完全缓解时间、凝血指标恢复正常时间、早期病死率进行比较。结果经治疗,实验组患者的症状完全缓解率、症状完全缓解时间、凝血指标恢复正常时间、早期病死率均优于对照组,两组的数据具有很大差别,差异具有统计学意义(P<0.05)。结论全反式维甲酸联合三氧化二砷的治疗方案会明显改善初发急性早幼粒细胞白血病患者的临床效果,能够显著降低病死率,有利于患者的生命健康安全。

Objective To investigate and analyze clinical effect of all trans retinoic acid combined with arsenic trioxide treating primary acute promyelocytic leukemia patients. Methods Choose 40 cases primary acute promyelocytic leukemia patients treated in our hospital from May 2012 to May 2017 randomly, divide them into control group 20 cases and experimental group 20 cases by casting lots. Two group received different medicine treatment. Control group were treated with all trans retinoic acid treatment, experimental group with all trans retinoic acid combined with arsenic trioxide treatment, observe and analyze clinical effect of two groups of primary acute promyelocytic leukemia patients, and compare complete symptoms remission rate, complete symptoms remission time, coagulation index recovery time, early mortality of two groups. Results After treatment, symptoms complete remission rate, symptoms complete remission time, coagulation index recovery time, early mortality of experimental group was better than control group, data difference showed statistical significance between two groups(P<0.05). Conclusion Treatment scheme of all trans retinoic acid combined with arsenic trioxide can improve clinical effect of primary acute promyelocytic leukemia patients significantly, reduce mortality rate, which is beneficial to patients' health and safety.