帕罗西汀治疗老年冠心病并发抑郁症的疗效观察

Observation on the Efficacy of Pa Rossi Dean in the Treatment of Senile Coronary Heart Disease Complicated with Depression

目的对老年冠心病并发抑郁症患者使用帕罗西汀进行治疗,观察、分析其治疗效果。方法选取我院自2012年3月至2016年7月收治的老年冠心病并发抑郁症共160例,分为对照组、治疗组各80例,对照组使用常规药物进行治疗,治疗组在对照组治疗的基础上,给予帕罗西汀进行治疗,剂量为每天20-40mg,以8周为总治疗疗程,观察分析两组的治疗效果、不良反应。结果经过8周的治疗,所有患者的汉密尔顿抑郁量表评分、同型半胱氨酸、超敏C反应蛋白、内皮依赖性血管扩张值指标,治疗后与治疗前相比均有好转,且具有统计学意义上的明显差异;治疗组与对照组相比,上述指标表现更优,且差异有统计学意义。冠心病症状改善,治疗组总有效率为66.25%,对照组总有效率为51.25%。结论使用帕罗西汀对老年冠心病并发抑郁症患者进行治疗,能够在较短的时间内取得良好的治疗效果,而且使用过程中不良反应少,具有较高的安全性。

Objective To observe and analyze the therapeutic effect of paroxetine in elderly patients with coronary heart disease. Methods Select our hospital from March 2012 to July 2016, a total of 160 patients with senile coronary heart disease(CHD) complicated with depression, were divided into control group and treatment group 80 examples, the control group using conventional drug treatment, treatment group given paroxetine treatment, dose of 20-40 mg a day, for 8 weeks treatment, observing and analyzing the therapeutic effect of two groups of patients, adverse reactions. Results After 8 weeks of treatment, all patients with Hamilton depression rating scale, homocysteine, hypersensitive c-reactive protein and endothelial dependent vasodilation value indicators, are improved compared with before treatment, after treatment with statistically significant difference; Compared with the control group, the above indexes showed better performance and statistically significant difference. The total effective rate of treatment group was 66.25%, and the total effective rate of control group was 51.25%. Conclusion Using paroxetine treating elderly patients with coronary heart disease complicated with depression, can in a relatively short period of time made good treatment effect, and less adverse reactions, in use process has high security.