比较泮托拉唑和奥美拉唑治疗胃溃疡的效果和安全性

Compare Effect and Safety of Pantoprazole and Omeprazole in Treatment of Gastric Ulcer

目的分析比较在治疗胃溃疡中泮托拉唑和奥美拉唑治疗效果以及安全性。方法将在我院门诊确诊的胃溃疡患者共48例,将其随机分为观察、对照两组组,各24例,观察组使用泮托拉唑进行治疗;对照组使用奥美拉唑进行治疗,对比两组患者在治疗后的实际效果、不良反应率以及复发率与对幽门螺杆菌的根除率。结果将两组患者治疗的总有效率以及各自的不良反应的发生率进行对比,差异细微(P>0.05),均无统计学意义;观察组患者胃溃疡的复发率显著低于对照组(P<0.05);观察组患者对幽门螺杆菌的根除率显著高于对照组(P<0.05),差异均有统计学意义。结论在治疗胃溃疡中,使用泮托拉唑以及奥美拉唑的治疗方式都有明显的疗效,且两种药物治疗后不良反应的发生率也相近,无明显差异,但使用泮托拉唑治疗的观察组患者有更好的治疗效果,胃部溃疡的愈合率也更高。

Objective To analyze and compare effect and safety of pantoprazole and omeprazole in treatment of gastric ulcer. Methods Divide 48 cases diagnosed gastric ulcer patients in outpatients of our hospital randomly into observation and control group, 24 cases in each. Observation group was treated with pantoprazole; and control group with omeprazole. Compare actual effect, adverse reaction rate and recurrence rate and HP eradication rate of two groups after treatment. Results Total effective rate and adverse reactions between two groups had subtle differences,(P>0.05), with no statistical significance; gastric ulcer recurrence rate of observation group was significantly lower than control group(P<0.05); Helicobacter pylori eradication rate of observation group was significantly higher than control group(P<0.05), differences showed statistical significance. Conclusion Both pantoprazole and omeprazole have obvious curative effect in treatment of gastric ulcer, and similar adverse reactions incidence after treatment with no significant difference. But pantoprazole has better curative effect for observation group, and higher healing rate for gastric ulcer.