兰索拉唑治疗消化道溃疡上消化道出血的临床疗效

Clinical Efficacy of Lansoprazole in the Treatment of Gastrointestinal Ulcer with Upper Gastrointestinal Bleeding

目的对兰索拉唑在消化道溃疡上消化道出血中的治疗效果进行探讨。方法依据研究纳入标准以及排除标准,将20例消化道溃疡上消化道出血患者列为我院研究对象,收治时间均为2017年7月至2018年7月,实施兰索拉唑+克拉霉素+阿莫西林治疗,为研究观察组。同期另外20例消化道溃疡上消化道出血患者则实施法莫替丁+克拉霉素+阿莫西林治疗,为研究参照组。就两组患者的临床治疗情况以及预后情况展开分析和数据对比。结果观察组的治疗总有效率与参照组相比更高,差异显著(P<0.05),有统计学意义;观察组的止血时间与参照组相比更短,Hp根除率与参照组相比更高,差异显著(P<0.05),有统计学意义;两组患者的不良反应发生率差异不明显(P> 0.05),无统计学意义。结论应用兰索拉唑对消化道溃疡上消化道出血患者进行治疗,疗效显著,止血效果理想,且具有较高安全性。

Objective To discuss the therapeutic effect of lansoprazole on gastrointestinal ulcer complicated withupper gastrointestinal bleeding. Methods According to the inclusion criteria and exclusion criteria of the study, 20 patients with gastrointestinal ulcer and upper gastrointestinal bleeding were included as the subjects of study in ourhospital from July 2017 to July 2018. They were treated with Lansoprazole+Clarithromycin+Amoxicillin, and set asthe observation group. In the same period, another 20 patients with gastrointestinal ulcer and upper gastrointestinalbleeding were treated with famotidine+clarithromycin+amoxicillin, as the reference group. Results The total effectiverate of the observation group was higher than that of the reference group, the difference was significant(P<0.05). Thehemostasis time of the observation group was shorter than that of the reference group, and the Hp eradication rate washigher compared with the reference group. The ratio was shorter and the difference was significant(P<0.05), whichwas statistically significant. There was no significant difference in the incidence of adverse reactions between the twogroups(P>0.05), which was not statistically significant. Conclusion Lansoprazole was used to treat patients withgastrointestinal ulcer and upper gastrointestinal hemorrhage. The curative effect was remarkable, the hemostasis effectwas ideal and the safety was high.