头孢菌素类抗菌药物不良反应临床分析

Clinical Analysis of Adverse Reactions of Cephalosporin Antibiotics

目的分析头孢菌素类抗菌药物不良反应及相应的防范措施。方法本次临床调查研究时间为2017年7月至2018年7月,对医院ADR监测中心收集到的89份头孢菌素类抗菌药物不良反应报告进行分析,探究患者不良反应症状、原因,并制定相应的防范策略。结果 (1)头孢菌素类抗菌药物之中,头孢曲松药物最易出现不良反,不良反应率为33.76%。(2)而头孢菌素类抗菌药物最易出现的不良反应表现为以皮肤系统为主的过敏反应,出现几率为43.82%。(3)静脉注射最易出现不良反应,不良反应率为50.57%,同时患者多在用药30 min内出现不良反应,发生几率为43.50%。结论头孢菌素类抗菌药物不良反应诸多,今后临床之中必须根据《临床用药须知》规定合理用药,从而保障患者健康安全。

Objective To analyze the adverse reactions of cephalosporin antibiotics and the corresponding preventive measures.Methods The clinical investigation time was from July 2017 to July 2018. The 89 cephalosporin antibiotics adverse reactions reported by the hospital ADR monitoring center were analyzed to explore the symptoms and causes of adverse reactions. Corresponding preventive strategies were formulated.Results Firstly, among the cephalosporin antibiotics, ceftriaxone was the most susceptible to adverse reactions, and the adverse reaction rate was 33.76%. Secondly, the most common adverse reactions of cephalosporin antibiotics are allergic reactions based on the skin system, with a probability of 43.82%. Thirdly, intravenous injection is the most prone to adverse reactions, the adverse reaction rate is 50.57%, and patients often have adverse reactions within 30 min of medication, the incidence rate is 43.50%.Conclusion The cephalosporin antibiotics have many adverse reactions. In the future, they must be rationally administered according to the 'Guidelines for Clinical Use' to ensure the health and safety of patients.