间歇性与持续性雄激素阻断治疗晚期前列腺癌的效果探讨

Effect of Intermittent and Continuous Androgen Blockade on Advanced Prostate Cancer

目的探讨间歇性雄激素阻断(IAD)与持续性雄激素阻断(CAD)治疗晚期前列腺癌的疗效。方法将82例晚期前列腺癌患者依据治疗方法的不同分成CAD组(42例)与IAD组(40例),对两组随访2年,观察两组治疗前后血清PSA水平变化、病情进展及不良反应发生情况。结果治疗后两组血清PSA均下降,并在6个月后下降到最低,之后上升并稳定在较低水平,但是血清PSA变化上两组无差异(P>0.05);CAD组疾病进展率及不良反应发生率分别为30.95%、26.19%,高于IAD组10.00%、7.50%的进展率及发生率(P<0.05)。结论 CAD与IAD治疗晚期前列腺癌的疗效无差异,但IAD安全性高,患者病情进展率低,可作为治疗首选。

Objective To investigate the efficacy of intermittent androgen blockade(IAD) and continuous androgen blockade(CAD) in the treatment of advanced prostate cancer.Methods Eighty-two patients with advanced prostate cancer were divided into CAD group(42 cases) and IAD group(40 cases) according to different treatment methods. The two groups were followed up for 2 years.The changes of serum PSA levels, progression of the disease and adverse reactions were observed before and after treatment.Results After treatment, serum PSA decreased in both groups, and decreased to the lowest level after 6 months, then increased and stabilized at a lower level, but there was no difference in serum PSA between the two groups(P>0.05).The disease progression rate and adverse reaction rate in the CAD group were 30.95% and 26.19%, respectively, which was higher than the progression rate and incidence rate of 10.00% and 7.50% in the IAD group(P<0.05).Conclusion There is no difference between the efficacy of CAD and IAD in the treatment of advanced prostate cancer, but the safety of IAD is high, and the progress rate of patients is low, which can be used as the first choice for treatment.