坎地沙坦治疗原发性高血压和慢性心力衰竭的疗效分析

Therapeutic Effect of Candesartan in the Treatment of Essential Hypertension And Chronic Heart Failure

目的探讨在原发性高血压合并慢性心力衰竭患者的治疗中应用药物坎地沙坦治疗的临床效果。方法对照组应用药物美托洛尔进行治疗,观察组患者在该治疗基础上联用药物坎地沙坦治疗。结果两组患者治疗前收缩压和舒张压均较高,且差异不显著(P>0.05);治疗后观察组患者收缩压和舒张压的降低幅度均高于对照组(P<0.05);两组患者治疗之前LVEDD和LVESD水平均较高,LVEF较低(P>0.05),治疗之后观察组患者的LVEDD、LVESD和LVEF指标的改善效果均好于对照组(P<0.05);两组组患者的药物不良反应率均是3.33%,无统计学意义(P>0.05)。结论在原发性高血压并发慢性心力衰竭患者治疗中应用药物坎地沙坦有利于改善患者血压水平和心功能,且药物安全性较高,该药物治疗方案值得在临床中加以应用并推广。

Objective To investigate the clinical effect of the drug candesartan in the treatment of patients with essential hypertension and chronic heart failure.Methods The control group was treated with metoprolol. The patients in the observation group were treated with the drug candesartan on the basis of this treatment.Results The systolic and diastolic blood pressures of the two groups were higher before treatment(P>0.05). The decrease of systolic blood pressure and diastolic blood pressure in the observation group were higher than those in the control group(P<0.05). Patients in the group had higher LVEDD and LVESD levels before treatment, and LVEF was lower(P>0.05).After treatment, the improvement of LVEDD, LVESD and LVEF in the observation group was better than that in the control group(P<0.05). The adverse drug reaction rate of the two groups was 3.33%, no statistical significance(P>0.05).Conclusion The application of candesartan in the treatment of patients with essential hypertension complicated with chronic heart failure is beneficial to improve blood pressure and heart function, and the drug safety is high. The drug treatment plan is worthy of application and promotion in clinical practice.