80例儿科呼吸系统反复感染患儿的临床治疗体会

Clinical Experience in the Treatment of 80 Children with Repeated Respiratory Infections in the Pediatric Department

目的探讨分析儿科呼吸系统反复感染患儿的临床治疗体会。方法以儿科2016年4月至2017年4月作为研究时间段,以此时间内儿科收治的呼吸系统反复感染患儿80例作为研究样本,随机分为对照组40例和观察组40例给予对照组患儿实施常规治疗方式,给予观察组患儿在常规治疗的基础上添加匹多莫德,对比两组患儿治疗效果、症状消失时间、血清免疫球蛋白以及细胞相关免疫指标变化情况。结果治疗总有效率相对比,观察组95%更高于对照组67.5%,两组差异对比具有显著统计学意义(P<0.05)。对照组患者治疗前后其CD4^+、CD8^+、CD4^+/CD8^+等细胞相关免疫指标对比无显著统计学意义(P>0.05)。观察组患者治疗后其CD4^+、CD8^+、CD4^+/CD8^+等细胞相关免疫指标和治疗前相比呈现显著上升趋势,其中CD8^+下降趋势最为显著,前后差异对比具有显著统计学意义(P<0.05)。结论针对儿科呼吸系统反复感染患儿应用免疫类和抗生素药物相结合治疗方式能有效缓解患儿临床症状,改善患儿细胞相关免疫学功能和血清免疫球蛋白,安全有效,患儿服药后无明显不良反应,值得临床推广和应用。

Objective To investigate the clinical experience of children with repeated infections in pediatric respiratory system. Methods From April 2016 to April 2017, the pediatrics were used as the study period. Eighty children with recurrent respiratory infections admitted to the pediatrics were selected as the study samples. They were randomly divided into the control group(40 cases) and the observation group(40 cases). The children in the group were treated with conventional treatment. The children in the observation group were given pidotimod on the basis of routine treatment. The treatment effect, time of disappearance of symptoms, serum immunoglobulin and cell-related immune indexes were compared between the two groups. Results The total effective rate of treatment was relatively high. 95% of the observation group was higher than 67.5% of the control group. The difference between the two groups was statistically significant(P<0.05). There were no statistically significant differences in cell-related immune indexes between CD4^+, CD8^+, CD4^+/CD8^+ before and after treatment in the control group(P>0.05). The cell-related immune indexes such as CD4^+, CD8^+, CD4^+/CD8^+ in the observation group showed a significant upward trend compared with that before treatment. The CD8^+ decline trend was the most significant, and the difference between the two groups was statistically significant(P<0.05). Conclusion The combination of immunological and antibiotic drugs for children with repeated respiratory infections in pediatric respiratory system can effectively alleviate the clinical symptoms of children, improve the cell-related immunological function and serum immunoglobulin, and it is safe and effective. Adverse reactions are worthy of clinical promotion and application.