术后调强放疗在宫颈癌患者中的应用及对Th1/Th2细胞因子的影响研究

Application of Postoperative Intensity Modulated Radiation Therapy in Patients with Cervical Cancer and its Effect on Th1/Th2 Cytokines

目的探究术后调强放疗在宫颈癌患者中的应用及对Th1、Th2细胞因子水平的影响、Th1/Th2细胞因子表达相关关系。方法选取2017年3月-2018年5月期间在我院接受治疗的90例宫颈癌患者作为本次研究对象,并将90例患者平均分为两组,即放疗组和未放疗组,每组各45例,对其进行FIGO临床分期,另选取75例正常的健康人作为对照组,检测所有参与研究对象的干扰素-y(IFN-y)、白介素-2(IL-2)等Th1细胞因子水平以及白介素-4(IL-4)、白介素-6(IL-6)等Th2细胞因子水平,计算Th1/Th2比值,观察放疗在宫颈癌患者术后的应用效果。结果随着宫颈癌临床分期的加重,研究组患者Th1/Th2细胞因子的比值逐渐降低(P<0.05);不同分化程度的宫颈癌患者血清IFN-y、IL-2、IL-4、IL-6水平无显著区别(P>0.05)。结论宫颈癌患者体内Th1、Th2细胞因子水平的变化与其病理分期、恶化程度密切相关,可能在宫颈癌的发展过程中有一定影响。

Objective To investigate the application of intensity modulated radiation therapy(IMRT) in patients with cervical cancer and its correlation with the levels of Th1 and Th2 cytokines and the expression of Th1/Th2 cytokines. Methods Ninety patients with cervical cancer who were treated in our hospital from March 2017 to May 2018 were selected as the subjects of this study. 90 patients were divided into two groups on average, namely, radiotherapy group and non-radiotherapy group, 45 cases in each group. The clinical stages of FIGO were performed. Another 75 healthy people were selected as the control group, and all the participants were tested. The levels of Th1 cytokines such as interferon-y(IFN-y), interleukin-2(IL-2) and Th2 cytokines such as interleukin-4(IL-4) and interleukin-6(IL-6) were measured. The Th1/Th2 ratio was calculated to observe the effect of radiotherapy on cervical cancer patients after operation. Results The levels of Th1/Th2 cytokines decreased gradually(P<0.05). The serum levels of IFN-y, IL-2, IL-4 and IL-6 were not significantly different in patients with grade D cervical cancer(P>0.05). Conclusion The changes of Th1 and Th2 cytokines in patients with cervical cancer are closely related to their pathological stages and deterioration, and may have some influence on the development of cervical cancer.