奥美拉唑治疗消化性溃疡出血的疗效观察

Omeprazole in the Treatment of Peptic Ulcer Bleeding

目的研讨消化性溃疡出血患者使用奥美拉唑口服的临床价值。方法本实验抽选我院2016年5月至2018年5月收治的76例消化性溃疡出血患者作为观察对象,按随机数表法划分患者至两组,Ⅰ组(n=38)接受雷尼替丁治疗,Ⅱ组(n=38)接受奥美拉唑口服,对比评估两组的临床疗效、平均输血量、平均止血时间及不良反应发生率等指标。结果Ⅰ、Ⅱ组在总有效率方面的对比,结果无统计学意义(P>0.05)。与Ⅰ组相比,Ⅱ组患者的平均输血量显著减少,平均止血时间显著缩短,结果有统计学意义(P<0.05)。对比Ⅰ组的副反应总发生率(21.1%),Ⅱ组总发生率(7.9%)显著降低,结果有统计学意义(P<0.05)。结论对消化性溃疡出血患者使用奥美拉唑治疗有确切的疗效,且能够有效缩短止血时间,减少出血量与副反应的发生,值得推荐。

Objective To study the clinical value of oral administration of omeprazole in patients with peptic ulcer hemorrhage. Methods This study selected from May 2016 to May 2018 treated 76 cases of peptic ulcer hemorrhage patients as research object, according to the stochastic indicator method divided to two groups of patients, Ⅰ group(n=38) ranitidine accept treatment, Ⅱ group(n=38) accept oral omeprazole, compared to evaluate the clinical efficacy of two groups, the average amount of blood transfusion, average bleeding time and incidence of adverse reactions such as index. Results The total effective rate Ⅰ, Ⅱ group in the aspects of comparison, the result has no statistical significance(P>0.05). Compared with group Ⅰ Ⅱ group of patients, on average, blood transfusion amount is significantly reduced, average hemostasis time significantly shortened, the result was statistically significant(P<0.05). Contrast Ⅰ group overall adverse event incidence(21.1%), Ⅱ group(7.9%), significantly reduce the incidence of the total, the result was statistically significant(P<0.05). Conclusion The use of omeprazole in the treatment of peptic ulcer hemorrhage has definite curative effect, and can effectively shorten the hemostatic time, reduce the amount of bleeding and the occurrence of side effects, which is worthy of recommendation.