分析不同抗病毒方案治疗艾滋病的临床疗效及不良反应

Analysis of Clinical Efficacy and Adverse Reactions of Different Antiviral Regimens in the Treatment of AIDS

目的研究分析对艾滋病患者行不同抗病毒方案治疗后的临床效果以及不良反应发生情况。方法随机抽取在2017年6月至2018年6月到我院就诊的110例艾滋病患者,根据治疗方式进行分组,划分为对照组(n=55)、观察组(n=55)。予以对照组实施齐多夫定、拉米夫定、依非韦伦进行治疗,予以观察组实施替诺福韦、拉米夫定、依非韦伦进行治疗,对两组患者治疗后的临床效果以及不良反应发生情况进行评价与比较。结果经过不同方式治疗后,同对照组进行比较,观察组CD_4^+T淋巴细胞计数在300个μL及以上的所占比重更高(P<0.05);观察组不良反应发生率更低(P<0.05)。结论针对艾滋病患者而言,选择替诺福韦、拉米夫定、依非韦伦方案治疗的效果更加理想,且不良反应发生率低,不失为一种有效且可靠的治疗方案,在临床中具有可观的价值。

Objective To analyze the clinical effects and adverse reactions of AIDS patients after treatment with different antiviral regimens. Methods A total of 110 AIDS patients who were admitted to our hospital from June 2017 to June 2018 were randomly selected and divided into control group(n=55) and observation group(n=55) according to the treatment. The control group was treated with zidovudine, lamivudine and efavirenz. The patients in the observation group were treated with tenofovir, lamivudine and efavirenz. The effects and the occurrence of adverse reactions were evaluated and compared. Results After treatment with different methods, compared with the control group, the CD4+T lymphocyte count in the observation group was higher in the proportion of 300 μL and above(P<0.05);the incidence of adverse reactions in the observation group was lower(P<0.05). Conclusion For AIDS patients, the treatment of tenofovir, lamivudine and efavirenz is more effective, and the incidence of adverse reactions is low. It is an effective and reliable treatment in clinical practice. It has considerable value.