四联疗法治疗幽门螺杆菌阳性消化性溃疡的疗效观察

Therapeutic Effect of Quadruple Therapy on Helicobacter Pylori-positive Peptic Ulcer

目的探讨四联疗法治疗幽门螺杆菌阳性消化性溃疡的疗效。方法纳入2015年1月至2018年12月于我院就诊的50例幽门螺杆菌(Hp)阳性消化性溃疡患者为研究对象,按双盲法将其分为观察组和对照组,各25例。对照组给予阿莫西林+克拉霉素+埃索美拉唑三联疗法,观察组实施兰索拉唑+阿莫西林+克拉霉素+呋喃唑酮四联疗法,对比两组疗效变化、溃疡愈合情况和Hp根除情况。结果观察组治疗总有效率(96.00%)高于对照组(76.00%)(P<0.05);观察组溃疡面愈合率和对照组对比无显著差异(P>0.05);但观察组Hp根除率(96.00%)高于对照组(80.00%)(P<0.05);两组不良反应发生率对比无显著差异(P>0.05)。结论在Hp感染阳性PU中应用四联疗法可以提高临床疗效,增加Hp根除率,值得应用。

Objective To investigate the efficacy of quadruple therapy in the treatment of Helicobacter pyloripositive peptic ulcer. Methods Fifty patients with Helicobacter pylori(Hp)-positive peptic ulcer who were admitted to our hospital from January 2015 to December 2018 were enrolled in the study, According to double blind method,the patients were divided into observation group and control group, 25 cases each. The control group was given amoxicillin + clarithromycin+esomeprazole triple therapy. The observation group was treated with lansoprazole+am oxicillin+clarithromycin + furazolidone quadruple therapy, and the curative effect, ulcer healing and Hp eradication were compared between the two groups. Results The total effective rate of the observation group(96.00%) was higher than that of the control group(76.00%)(P<0.05). There was no significant difference in ulcer healing rate between the observation group and the control group(P>0.05). However, the observation group Hp eradication rate(96.00%) was higher than that of the control group(80.00%)(P<0.05). There was no significant difference in the incidence of adverse reactions between the two groups(P>0.05). Conclusion The application of quadruple therapy in Hp-positive PU can improve clinical efficacy and increase Hp eradication rate, which is worthy of application.