奥美拉唑联合法莫替丁治疗十二指肠溃疡的效果分析

Efficacy of Omeprazole Combined with Famotidine in the Treatment of Duodenal Ulcer

目的研究奥美拉唑联合法莫替丁治疗十二指肠溃疡的效果。方法选择十二指肠溃疡患者作为本次研究对象,并采用"电脑随机法"将200例十二指肠溃疡患者进行分组,主要包括两组,其中观察组实施奥美拉唑联合法莫替丁治疗,对照组实施奥美拉唑治疗,分析两组治疗效果、症状改善时间以及胃肠激素水平。结果观察组十二指肠溃疡患者治疗总有效率为96.00%,高于对照组,两组差异具有统计学意义,P<0.05。观察组十二指肠溃疡患者溃疡痛消失时间、烧心消失时间、反酸消失时间均短于对照组,P<0.05。观察组十二指肠溃疡患者AM(41.94±1.74)pg.mL-1、GAS(61.20±1.73)pg.mL-1低于对照组,CGRP(16.70±1.29)pg.mL-1、SS(13.99±1.23)pg.mL-1高于对照组,差异有统计学意义,P<0.05。结论奥美拉唑联合法莫替丁治疗十二指肠溃疡的效果十分显著,且安全性高。

Objective To study the effect of omeprazole combined with famotidine in the treatment of duodenal ulcer. Methods The patients with duodenal ulcer were selected as the research object, and 200 patients with duodenal ulcer were divided into two groups by 'computer random method', the observation group was treated with omeprazole combined with famotidine, while the control group was treated with omeprazole, the therapeutic effect,the improvement time of symptoms and the level of gastrointestinal hormones in the two groups were analyzed.Results The total effective rate of duodenal ulcer patients in the observation group was 96.00% higher than that in the control group, there was a significant difference between the two groups, P<0.05. The time of ulcer pain disappearance,heartburn disappearance and acid regurgitation disappearance in the observation group were shorter than those in the control group(P<0.05). The AM(41.94±1.74)pg.mL-1、GAS(61.20±1.73)pg.mL-1 in the observation group were lower than those in the control group, CGRP(16.70±1.29)pg.mL-1、SS(13.99±1.23)pg.mL-1 in the observation group were higher than those in the control group, the difference was statistically significant(P< 0.05). Conclusion Omeprazole combined with famotidine is effective and safe in the treatment of duodenal ulcer.