分析H型高血压患者血管内皮功能变化及与血浆同型半胱氨酸水平的关系

Analysis of Changes in Vascular Endothelial Function and Plasma Homocysteine Levels in Patients with Type H Hypertension

目的探讨H型高血压患者血管内皮功能变化及与血浆同型半胱氨酸水平的关系。方法选择于2015年10月至2018年10月到我院接受诊疗的150例原发性高血压患者。根据血浆同型半胱氨酸水平(Hcy)分为两组。对照组63例患者Hcy<10μmol/L。观察组87例患者Hcy≥10μmol/L。同时选取62例健康体检者作为参照组。检测三组患者一氧化氮等血管内皮功能指标。结果观察组87例患者血管内皮功能指标水平明显差于对照组63例患者、参照组62例健康体检者,对照组血管内皮功能明显差于参照组,均差异显著(P<0.05)。结论血浆Hcy水平越高,血浆内皮素水平越高,一氧化氮活性下降越明显,血管内皮功能更容易发生障碍,值得临床注意。

Objective To investigate the relationship between vascular endothelial function and plasma homocysteine levels in patients with type H hypertension. Methods One hundred and fifty patients with essential hypertension who were admitted to our hospital from October 2015 to October 2018 were selected. They were divided into two groups based on plasma homocysteine levels(Hcy). In the control group, 63 patients had Hcy<10μmol/L. Eighty-seven patients in the observation group had Hcy≥10μmol/L. At the same time, 62 healthy subjects were selected as the reference group. Three groups of patients were tested for vascular endothelial function such as nitric oxide. Results The vascular endothelial function index of 87 patients in the observation group was significantly worse than that in the control group of 63 patients and the reference group of 62 healthy subjects. The vascular endothelial function of the control group was significantly worse than that of the reference group, and the difference was significant(P<0.05). Conclusion The higher the plasma Hcy level, the higher the plasma endothelin level, the more obvious the decrease of nitric oxide activity, and the vascular endothelial function is more likely to cause obstacles, which is worthy of clinical attention.