探析地屈孕酮用于先兆流产保胎治疗的临床疗效

To Investigate the Clinical Efficacy of Dydrogesterone in the Treatment of Threatened Abortion

目的研讨先兆流产患者使用地屈孕酮进行保胎治疗的临床价值。方法以我院收治于2012年1月至2018年10月的80例先兆流产患者作为观察对象,并以随机抽签模式进行研究分组,A组(n=40)使用黄体酮保胎,B组(n=40)给予地屈孕酮用药,分析评估两组用药的临床结局。结果 (1)A组与B组的保胎成功率及不良反应率分析:A、B组保胎成功率依次达到87.5%与92.5%,不良反应率依次为7.5%与5.0%,对比P>0.05,无统计学意义;(2)A组与B组不同孕期的血清孕酮检测水平分析:两组孕7～10周的血清孕酮检测值较孕6周均显著提高,P<0.05,有统计学意义;但组间比较,P>0.05,无统计学意义。结论对先兆流产患者使用地屈孕酮治疗,可获得与黄体酮相当的保胎效果,值得推荐。

Objective To study the clinical value of dydrogesterone in patients with threatened abortion. Methods Eighty patients with threatened abortions admitted to our hospital from January 2012 to October 2018 were enrolled in the study and randomized in a randomized mode. Group A(n=40) was treated with progesterone, group B(n=40).The drug was administered to dydrogesterone, and the clinical outcomes of the two groups of drugs were analyzed and evaluated. Results(1) Analysis of the success rate and adverse reaction rate of group A and group B: The success rate of group A and group B reached 87.5% and 92.5%, and the adverse reaction rate was 7.5% and 5.0%, respectively.P>0.05, no statistical significance;(2) Analysis of serum progesterone levels in group A and group B during different pregnancy periods: serum progesterone levels in 7 to 10 weeks of pregnancy were significantly higher than those in 6 weeks of pregnancy, P<0.05, statistically significant;but the comparison between groups, P>0.05, no statistical significance. Conclusion For patients with threatened abortion using dydrogesterone treatment, can obtain the same effect as progesterone, it is recommended.