泮托拉唑治疗消化性溃疡合并上消化道出血的临床分析

Clinical Analysis of Pantoprazole in the Treatment of Peptic Ulcer Complicated with Upper Gastrointestinal Bleeding

目的观察分析泮托拉唑治疗消化性溃疡合并上消化道出血的临床效果。方法选择自2016年2月至2019年2月我院收治的18例消化性溃疡合并上消化道出血患者为观察对象,对所有患者均给予泮托拉唑进行治疗,观察所有患者在经治疗后的临床效果。结果 (1)所有患者治疗后临床效果与不良反应发生情况:所有患者在经治疗后,其中显效12(66.7%)例、好转5(27.7%)例、无效1(5.6%)例,总有效率为94.4%;不良反应共2例,其中呕吐1例、头痛1例,无口干现象,不良反应总发生率为11.1%;(2)所有患者治疗前后呕血与黑便次数对比:所有患者经治疗后,其呕血与黑便发生次数相比较治疗前明显大幅度减少,前后对比差异具有统计学意义(P<0.05)。结论对消化性溃疡合并上消化道出血患者给予泮托拉唑治疗,其治疗效果显著,不良反应发生率低,可改善其不良症状,值得在临床治疗中推广应用。

Objective To observe the clinical effect of pantoprazole in the treatment of peptic ulcer with upper gastrointestinal hemorrhage.Methods Eighteen patients with peptic ulcer complicated with upper gastrointestinal hemorrhage admitted to our hospital from February 2016 to February 2019 were enrolled.All patients were treated with pantoprazole.All patients were treated.After the clinical effect.Results(1)Clinical outcomes and adverse reactions after treatment in all patients:All the patients in the after treatment,Among them,12(66.7%)had marked effect,5(27.7%)cases improved,1(5.6%)cases were invalid,the total effective rate was 94.4%;2 cases of adverse reactions,including 1 case of vomiting,1 case of headache,no dry mouth,the overall incidence of adverse reactions was 11.1%;(2)Comparing the number of hematemesis and blackstool before and after treatment in all patients:After treatment,the number of hematemesis and blackstool was significantly reduced compared with before treatment,and the difference was statistically significant(P<0.05).Conclusion Pantoprazole is effective in the treatment of peptic ulcer complicated with upper gastrointestinal bleeding.The incidence of adverse reactions is low.It can improve the adverse symptoms of peptic ulcer.It is worth popularizing in clinical treatment.