硝酸盐转运蛋白（Sialin）与口腔癌的相关性研究

Study on Correlation between Nitrate Transporter(Sialin) and Oral Cancer

目的探究硝酸盐转运蛋白与口腔癌的相关性。方法收集2018年1月至2018年8月我院收治口腔癌患者50例,取其口腔癌组织和癌旁组织,同时取50例健康人的正常口腔组织作为对照,进行免疫组织化学染色,并进行阳性评定,比较三者阳性表达率,统计Sialin表达与口腔癌临床因素的相关性。结果口腔癌组织中阳性表达率为94.00%,癌旁组织为62.00%,显著高于正常组织(P<0.05);Sialin的表达与口腔癌的分期和分化程度有关(P<0.05)。结论 Sialin表达在口腔癌的发生发展中具有重要作用,对口腔癌的诊断分期具有一定的临床意义。

Objective To explore correlation between nitrate transporter and oral cancer.Methods Collect 50 cases oral cancer patients in our hospital from January 2018 to August 2018.Take oral cancer tissues and paracancerous tissues,and normal tissues of 50 cases healthy people as controls.Carry on immunohistochemical staining and positive evaluation.Compare their positive expression rates and count correlation between Sialin expression and clinical causes of oral cancer.Results Positive expression rate of oral cancer was 94.00%,that in paracancerous tissues was 62.00%,which was significantly higher than normal tissues(P<0.05).Expression of Sialin was related to staging and differentiation degree of oral cancer(P<0.05).Conclusion Sialin expression plays an important role in occurrence and development of oral cancer,and has certain clinical significance in diagnosis and staging of oral cancer.