对慢性萎缩性胃炎患者的危险因素及其临床治疗效果分析

Analysis of Risk Factors and Clinical Treatment Effects in Patients with Chronic Atrophic Gastritis

目的对慢性萎缩性胃炎患者的危险因素以及治疗效果进行探讨。方法研究对象筛选基于纳入标准和排除标准作为前提,抽选2018年6月至2019年1月选取的慢性萎缩性胃炎患者400例,设为观察组,临床上再将其分成两组,观察A组200例,予以三联疗法+替普瑞酮治疗;观察B组200例,予以三联疗法+替普瑞酮+叶酸治疗。于相同时间段另选慢性非萎缩性胃炎患者400例,设为参照组。比较和分析观察组和参照组,总结危险因素,同时比较两组观察组的治疗效果。结果观察组与参照组对比显示,单因素分析得出,相对参照组,观察组年龄>60岁、存在胆汁反流、家族胃癌史、饮食习惯不良、Hp感染率更高,数据对比显示差异较大且P<0.05,统计学意义成立;多因素分析显示,年龄、家族胃癌史、胆汁反流史、幽门螺杆菌感染均为慢性萎缩性胃炎危险因素。在治疗效果方面,相对观察组A,观察组B总有效率更高,数据对比显示差异较大且P<0.05,统计学意义成立。结论慢性萎缩性胃炎的危险因素较多,在治疗方法应用三联疗法+替普瑞酮+叶酸具有显著效果。

Objective To investigate the risk factors and therapeutic effects of patients with chronic atrophic gastritis.Methods The screening of the subjects was based on the inclusion criteria and exclusion criteria.The selection period was from June 2018 to January 2019.A total of 400 patients with chronic atrophic gastritis were selected and placed in the observation group.In clinic,they were divided into two groups.200 cases in group A were observed and treated with triple therapy plus teprenone.Observation group B Two hundred cases,triple therapy+teprenone+folic acid treatment.Another 400 patients with chronic non-atrophic gastritis were selected at the same time period and used as reference group.The observation group and the reference group were compared and analyzed,the risk factors were summarized,and the therapeutic effects of the two groups were compared.Results The comparison between the observation group and the reference group showed that the age of the observation group was>60 years old,the presence of bile reflux,family history of gastric cancer,poor eating habits,and higher Hp infection rate.Data comparison showed that the difference was significant(P<0.05),and the statistical significance was valid;multivariate analysis showed that age,family history of gastric cancer,history of bile reflux,and Helicobacter pylori infection were risk factors for chronic atrophic gastritis.In terms of therapeutic effect,compared with observation group A,the total effective rate of observation group B was higher,and the data comparison showed a large difference and P<0.05,and the statistical significance was established.Conclusion There are many risk factors for chronic atrophic gastritis.The combination of triple therapy+teprenone+folic acid has a significant effect in the treatment.