聚醚醚酮植入材料接枝改性的研究进展

Research progress on the grafting modification of poly(ether-ether-ketone) implant materials

聚醚醚酮具有耐高温、耐摩擦、耐腐蚀等一系列优点,成为口腔种植领域的新兴材料,但本身的生物惰性不利于细胞黏附与增殖。传统方法如化学处理和共混改性等具有减弱机械性能、改性后维持时间短等缺点,而接枝改性方法由于只在表面发生反应,可以保存PEEK(Poly ether ether ketone,PEEK)优良的机械性能;接枝单体的活性基团与PEEK表面引入的极性基团形成共价结合,可以延长亲水性表面的维持时间,从而使其生物活性得以稳定而持久的增强。本文主要对常用的接枝改性方法加以综述。

Poly(ether-ether-ketone), with a series of advantages such as high temperature resistance, friction resistance and corrosion resistance, has become a new material in oral implant field, but its biological inertia is not conducive to cell adhesion and proliferation. Traditional methods such as chemical treatment and blending modification have disadvantages such as weakened mechanical properties and short maintenance time after modification, while grafting modification method can preserve the excellent mechanical properties of PEEK because it only reacts on the surface. The active group of the graft monomer can form covalent bond with the polar group introduced on PEEK surface, which can extend the maintenance time of the hydrophilic surface and thus enhance its biological activity stably and permanently In this paper, the common methods of graft modification are reviewed.