靶向肿瘤相关巨噬细胞治疗卵巢癌的研究进展

Advances in Immunotherapy Targeting Tumor-associated Macrophages for Ovarian Cancer

卵巢癌是女性生殖系统中致死率最高的恶性肿瘤,严重威胁着女性的健康。近年来越来越多的研究关注到卵巢癌与其所处免疫微环境之间的相互作用。肿瘤相关巨噬细胞是肿瘤免疫微环境中数量最多的免疫细胞,贯穿了卵巢癌发生、发展的各个阶段。多项临床研究已经证实肿瘤相关巨噬细胞的数量及极化状态与卵巢癌患者的预后密切相关。本文概述了直接靶向肿瘤相关巨噬细胞的临床研究进展,以期对卵巢癌的临床治疗提供参考。

Ovarian cancer has the highest mortality rate among gynecologic malignancies,which is a serious threat to women’s health. In recent years,more and more studies have shown the interaction between the ovarian cancer and its immune microenvironment. Tumor-associated macrophages(TAMs) are the most numerous immune cells in the tumor microenvironment,it plays an important role in the development of ovarian cancer. This article reviews the research progress of clinical strategies that directly targeting TAMs,to provide reference for the clinical treatment of ovarian cancer.